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Publications

See how top researchers are using our technology to predict durable responses and unlock pre-clinical meaning.

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  • Cancer Immunology
  • Cellular and Regenerative Medicine
  • Inflammation & Neurology
  • Oncology
  • Vaccines & Infectious Disease
Cancer Immunology
Immune checkpoint blockade induces gut microbiota translocation that augments extraintestinal antitumor immunity
Choi Y, Lichterman JN, Coughlin LA, Poulides N, Li W, Del Valle P, Palmer SN, Gan S, Kim J, Zhan X, Gao Y, Evers BM, Hooper LV, Chandrashekhar P, Koh AY Science Immunology. 2023.
Cancer Immunology, Vaccines & Infectious Disease
Clinical trials of self-replicating RNA-based cancer vaccines
Morse MA, Crosby EJ, Force J, Osada T, Hobeika AC, Hartman ZC, Berglund P, Smith J, Lyerly HK Cancer Gene Therapy . 2023.
Cancer Immunology
Immunotoxin-αCD40 therapy activates innate and adaptive immunity and generates a durable antitumor response in glioblastoma models
Parker S, McDowall C, Sanchez-Perez L, Osorio C, Duncker PC, Briley A, Swartz AM, Herndon II JE, Yu YA, McLendon RE, Tedder TF, Desjardins A, Ashley DM, Gunn MD, Enterline DS, Knorr DA, Pastan IH, Nair SK, Bigner DD, Chandramohan V Science Translational Medicine. 2023.
Cellular and Regenerative Medicine
Synapse-tuned CARs enhance immune cell anti-tumor activity
Chockley PJ, Ibanez-Vega J, Krenciute G, Talbot LJ, Gottschalk S Nature Biotechnology. 2023.
Cancer Immunology
Proteolytic regulation of CD73 by TRIM21 orchestrates tumor immunogenicity
Fu Z, Chen S, Zhu Y, Zhang D, Xie P, Jiao Q, Chi J, Xu S, Xue Y, Lu X, Song X, Cristofanilli M, Gradishar WJ, Kalinsky K, Yin Y, Zhang B, Wan Y Science Advances. 2023.
Cancer Immunology
Metformin increases natural killer cell functions in head and neck squamous cell carcinoma through CXCL1 inhibition
Crist M, Yaniv B, Palackdharry S, Lehn MA, Medvedovic M, Stone T, Gulati S, Karivedu V, Borchers M, Fuhrman B, Crago A, Curry J, Martinez-Outschoorn U, Takiar V, Wise-Draper TM Journal for ImmunoTherapy of Cancer. 2022.
Cancer Immunology
First-in-human phase I/II, open-label study of the anti-OX40 agonist INCAGN01949 in patients with advanced solid tumors
Davis EJ, Martin-Liberal J, Kristeleit R, Cho DC, Blagden SP, Berthold D, Cardin DB, Vieito M, Miller RE, Dass PH, Orcurto A, Spencer K, Janik JE, Clark J, Condamine T, Pulini J, Chen Xuejun, Mehnert JM Journal for ImmunoTherapy of Cancer. 2022.
Inflammation & Neurology
Effector Memory–Expressing CD45RA (TEMRA) CD8+ T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor–Dependent Proinflammatory and Migratory Responses
Doan Ngoc TM, Tilly G, Danger R, Bonizec O, Masset C, Guérif P, Bruneau S, Glemain A, Harb J, Cadoux M, Vivet A, Le Mai H, Garcia A, Laplaud D, Liblau R, Giral M, Blandin S, Feyeux M, Dubreuil L, Pecqueur C, Cyr M, Ni W, Brouard S, Degauque N Journal of the American Society of Nephrology. 2022.
Cancer Immunology
Distinct immune signature predicts progression of vestibular schwannoma and unveils a possible viral etiology
Amit M, Xie T, Gleber-Netto FO, Hunt PJ, Mehta GU, Bell D, Silverman DA, Yaman I, Ye Y, Burks JK, Fuller GN, Gidley PW, Nader ME, Raza SM, DeMonte F Journal of Experimental & Clinical Cancer Research. 2022.
Cancer Immunology
Secreted Fas decoys enhance the antitumor activity of engineered and bystander T cells in Fas ligand–expressing solid tumors
Bajgain P, Torres Chavez AG, Balasubramanian K, Fleckenstein L, Lulla P, Heslop HE, Vera J, Leen AM Cancer Immunology Research. 2022.
Cancer Immunology
Inhibition of integrin αVβ3 signaling improves the antineoplastic effect of bexarotene in cutaneous T-cell lymphoma
Cayrol F, Revuelta MV, Debernardi M, Paulazo A, Phillip JM, Zamponi N, Sterle HA, Díaz Flaqué MC, Magro CM, Marullo R, Mulvey E, Ruan J, Cremaschi GA, Cerchietti L Molecular Cancer Therapeutics. 2022.
Cellular and Regenerative Medicine
Transgenic expression of IL-7 regulates CAR-T cell metabolism and enhances in vivo persistence against tumor cells
Li L, Li Q, Yan ZX, Sheng LS, Fu D, Xu P, Wang L, Zhao WL Scientific Reports. 2022.
Cellular and Regenerative Medicine
A long-acting interleukin-7, rhIL-7-hyFc, enhances CAR T cell expansion, persistence, and anti-tumor activity
Kim MY, Jayasinghe R, Devenport JM, Ritchey JK, Rettig MP, O’Neal J, Staser KW, Kennerly KM, Carter AJ, Gao F, Lee BH, Cooper ML & DiPersio JF Nature Communications. 2022.
Cellular and Regenerative Medicine
Single-cell antigen-specific landscape of CAR T infusion product identifies determinants of CD19-positive relapse in patients with ALL
Bai Z, Woodhouse S, Zhao Z, Arya R, Govek K, Kim D, Lundh S, Baysoy A, Sun H, Deng Y, Xiao Y, Barrett DM, Myers RM, Grupp SA, June CH, Fan R, Camara PG, Melenhorst JJ Science Advances. 2022.
Cellular and Regenerative Medicine
Enabling Allogeneic T Cell-Based Therapies: Scalable Stirred-Tank Bioreactor Mediated Manufacturing
Gatla H, Uth N, Levinson Y, Navaei A, Sargent A, Ramaswamy S, Ben-Nun IF Frontiers in Medical Technology. 2022.
Cancer Immunology
Bispecific targeting of CD20 and CD19 increases polyfunctionality of chimeric antigen receptor T-cell products in B-cell malignancies
Zurko JC, Xu H, Chaney K, Schneider D, Szabo A, Hari P, Johnson BD, Shah NN Cytotherapy. 2022.
Cellular and Regenerative Medicine
Cytosine Base Editing Enables Quadruple-Edited Allogeneic CAR-T Cells for T-ALL
Diorio C, Murray R, Naniong M, Barrera LA, Camblin AJ, Chukinas JA, Coholan L, Edwards A, Fuller T, Gonzales C, Grupp SA, Ladd AM, Buttimer Le M, Messana A, Musenge F, Newman H, Poh YC, Poulin H, Ryan T, Shraim R, Tasian SK, Vincent TL, Young L, Zhang Y, Ciaramella G, Gehrke J, Teachey DT Blood. 2022.
Cancer Immunology
Transgenic Expression of IL15 Retains CD123-Redirected T Cells in a Less Differentiated State Resulting in Improved Anti-AML Activity in Autologous AML PDX Models
Mu-Mosley H, Ostermann L, Muftuoglu M, Vaidya A, Bonifant CL, Velasquez MP, Gottschalk S, Andreeff M Frontiers in Immunology. 2022.
Cancer Immunology
CCL22 mutations drive natural killer cell lymphoproliferative disease by deregulating microenvironmental crosstalk
Baer C, Kimura S, Rana MS, Kleist AB, Flerlage T, Feith DJ, Chockley P, Walter W, Meggendorfer M, Olson TL, Cheon H, Olson KC, Ratan A, Mueller ML, Foran JM, Janke LJ, Qu C, Porter SN, Pruett-Miller SM, Kalathur RC, Haferlach C, Kern W, Paietta E, Thomas PG, Babu MM, Loughran Jr. TP, Iacobucci I, Haferlach T, Mullighan CG Nature Genetics. 2022.
Cellular and Regenerative Medicine
T-Cells Expressing a Highly Potent PRAME-Specific T-Cell Receptor in Combination with a Chimeric PD1-41BB Co-Stimulatory Receptor Show a Favorable Preclinical Safety Profile and Strong Anti-Tumor Reactivity
Sailer N, Fetzer I, Salvermoser M, Braun M, Brechtefeld D, Krendl C, Geiger C, Mutze K, Noessner E, Schendel DJ, Bürdek M, Wilde S, Sommermeyer D Cancers. 2022.
Cancer Immunology
Cell-directed aptamer therapeutic targeting for cancers including those within the central nervous system
Wei J, Song R, Sabbagh A, Marisetty A, Shukla N, Fang D, Najem H, Ott M, Long J, Zhai L, Lesniak MS, James CD, Platanias L, Curran M, Heimberger AB OncoImmunology. 2022.
Vaccines & Infectious Disease
In-depth analysis of SARS-CoV-2-specific T cells reveals diverse differentiation hierarchies in vaccinated individuals
Li L, Muftuoglu M, Liang S, Basyal M, LV J, Akdogan ME, Chen K, Andreeff M, Parmar S JCI Insight. 2022.
Cellular and Regenerative Medicine
Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets
Fernandez-Yague MA, Hymel LA, Olingy CE, McClain C, Ogle ME, García JR, Minshew D, Vyshnya S, Seo Lim H, Qiu P, García AJ, Botchwey EA Science Advances. 2022.
Vaccines & Infectious Disease
Multiple Early Factors Anticipate Post-Acute COVID-19 Sequelae
Su Y, Yuan D, Chen DG, Ng RH, Wang K, Choi J, Li S, Hong S, Zhang R, Xie J, Kornilov SA, Scherler K, Pavlovitch-Bedzyk AJ, Dong S, Lausted C, Lee I, Fallen S, Dai CL, Baloni P, Smith B, Duvvuri VR, Anderson KG, Li J, Yang F, Duncombe CJ, McCulloch DJ, Rostomily C, Troisch P, Zhou J, Mackay S, DeGottardi Q, May DH, Taniguchi R, Gittelman RM, Klinger M, Snyder TM, Roper R, Wojciechowska G, Murray K, Edmark R, Evans S, Jones L, Zhou Y, Rowen L, Liu R, Chour W, Algren HA, Berrington WR, Wallick JA, Cochran RA, Micikas ME, the ISB-Swedish COVID19 Biobanking Unit, Wrin T, Petropoulos CJ, Cole HR, Fischer TD, Wei W, Hoon DSB, Price ND, Subramanian N, Hill JA, Hadlock J, Magis AT, Ribas A, Lanier LL, Boyd SD, Bluestone JA, Chu H, Hood L, Gottardo R, Greenberg PD, Davis MM, Goldman JD, Heath JR Cell. 2022.
Cancer Immunology
Ipilimumab alone or in combination with nivolumab in patients with advanced melanoma who have progressed or relapsed on PD-1 blockade: clinical outcomes and translational biomarker analyses
Friedman CF, Spencer C, Cabanski CR, Panageas KS, Wells DK, Ribas A, Tawbi H, Tsai K, Postow M, Shoushtari A, Chapman P, Karakunnel J, Bucktrout S, Gherardini P, Hollmann TJ, Chen RO, Callahan M, LaVallee T, Ibrahim R, Wolchok J Journal for ImmunoTherapy of Cancer. 2022.
Cellular and Regenerative Medicine
Benign tumors in TSC are amenable to treatment by GD3 CAR T cells in mice
Thomas A, Sumughan S, Dellacecca ER, Shivde RS, Lancki N, Mukhatayev Z, Vaca CC, Han F, Barse L, Henning SW, Zamora-Pineda J, Akhtar S, Gupta N, Zahid JO, Zack SR, Ramesh P, Jaishankar D, Lo ASY, Moss J, Picken MM, Darling TN, Scholtens DN, Dilling DF, Junghans RP, and Le Poole IC JCI Insight. 2021.
Cancer Immunology
Prognostic Value of Early Fluorodeoxyglucose-Positron Emission Tomography Response Imaging and Peripheral Immunologic Biomarkers: Substudy of a Phase II Trial of Risk-Adaptive Chemoradiation for Unresectable Non-Small Cell Lung Cancer
Bowen SR, Hippe DS, Thomas HM, Sasidharan B, Lampe PD, Baik Eaton KD, Lee S, Martins RG, Santana-Davila R, Chen DL, Kinahan PE, Miyaoka RS, Vesselle HJ, McGarry Houghton A, Rengan R, Zeng J Advances in Radiation Oncology. 2021.
Cellular and Regenerative Medicine
4-1BB and optimized CD28 co-stimulation enhances function of human mono-specific and bi-specific third-generation CAR T cells
Roselli E, Boucher JC, Li G, Kotani H, Spitler K, Reid K, Cervantes EV, Bulliard Y, Tu N, Lee SB, Yu B, Locke FL, Davila ML Journal for ImmunoTherapy of Cancer. 2021.
Cancer Immunology
Single-cell Polyfunctional Proteomics of CD4 Cells from Patients with AML Predicts Responses to Anti-PD-1-based therapy
Abbas H, Alaniz Z, Mackay SG, Cyr M, Zhou J, Issa GC, Alfayez M,Matthews J, Kornblau SM, Jabbour EJ, Garcia-Manero G, Konopleva MY, Andreeff M, Daver NG Blood Advances. 2021.
Cellular and Regenerative Medicine
Sulfated Alginate Hydrogels Prolong the Therapeutic Potential of MSC Spheroids by Sequestering the Secretome
Gionet-Gonzales M, Casella A, Diloretto D, Ginnell C, Griffin KH, Bigot A, Leach JK Advanced Healthcare Materials. 2021.
Cancer Immunology
Tumor-infiltrating lymphocyte treatment for anti-PD-1-resistant metastatic lung cancer: a phase 1 trial
Creelan BC, Wang C, Teer JK, Toloza EM, Yao J, Kim S, Landin AM, Mullinax JE, Saller JJ, Saltos AN, Noyes DR, Montoya LB, Curry W, Pilon-Thomas SA, Chiappori AA, Tanvetyanon T, Kaye FJ, Thompson ZJ, Yoder SJ, Fang B, Koomen JM, Sarnaik AA, Chen DT, Conejo-Garcia JR, Haura EB, Antonia SJ Nature Medicine. 2021.
Cellular and Regenerative Medicine
CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
Spiegel JY, Patel S, Muffly L, Hossain NM, Oak J, Baird JH, Frank MJ, Shiraz P, Sahaf B, Craig J, Iglesias M, Younes S, Natkunam Y, Ozawa MG, Yang E, Tamaresis J, Chinnasamy H, Ehlinger Z, Reynolds W, Lynn R, Rotiroti MC, Gkitsas N, Arai S, Johnston L, Lowsky R, Majzner RG, Meyer E, Negrin RS, Rezvani AR, Sidana S, Shizuru J, Weng WK, Mullins C, Jacob A, Kirsch I, Bazzano M, Zhou J, Mackay S, Bornheimer SJ, Schultz L, Ramakrishna S, Davis KL, Kong KA, Shah NN, Qin H, Fry T, Feldman S, Mackall CL, Miklos DB Nature Medicine. 2021.
Cancer Immunology
Tumor-derived NKG2D ligand sMIC reprograms NK cells to an inflammatory phenotype through CBM signalosome activation
Dhar P, Basher F, Ji Z, Huang L, Qin S, Wainwright DA, Robinson J, Hagler S, Zhou J, MacKay S, Wu JD Communications Biology. 2021.
Cancer Immunology
Venetoclax enhances T cell–mediated antileukemic activity by increasing ROS production
BokLee J, Khan DH, Hurren R, Xu M, Na Y, Kang H, Mirali S, Wang X, Gronda M, Jitkova Y, MacLean N, Arruda A, Alaniz Z, Konopleva MY, Andreeff M, Minden MD, Zhang L, Schimmer AD Blood. 2021.
Cancer Immunology
Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma
Diab A, Tykodi SS, Daniels GA, Maio M, Curti BD, Lewis KD, Jang S, Kalinka E, Puzanov I, Spira AI, Cho DC, Guan S, Puente E, Nguyen T, Hoch U, Currie SL, Lin W, Tagliaferri MA, Zalevsky J, Sznol M, Hurwitz ME Journal of Clinical Oncology. 2021.
Cellular and Regenerative Medicine
Transient blockade of TBK1/IKKε allows efficient transduction of primary human natural killer cells with vesicular stomatitis virus G-pseudotyped lentiviral vectors
Chockley P, Patil SL, Gottschalk S Cytotherapy. 2021.
Cancer Immunology
Synchronous effects of targeted mitochondrial complex I inhibitors on tumor and immune cells abrogate melanoma progression
Mahmoud A, McAllister DM, McOlash L, Cleland Harwig M, Cheng G, Drouillard D, Boyle KA, Hardy M, Zielonka J, Johnson BD, Hill RB, Kalyanaraman B, Dwinell MB iScience. 2021.
Cancer Immunology, Cellular and Regenerative Medicine
Comprehensive Activation Profiling of Tabelecleucel, an Off-The-Shelf, Allogeneic EBV-Specific T-Cell Immunotherapy
Ruiz F, Jehng T, Spindler T, Munson D, Karlen J, Thota V, Wang A, Chuan J, Yedwabnick M, Dubovsky J, Aftab BT Hematological Oncology. 2021.
Cancer Immunology
NF-κB c-Rel Is Dispensable for the Development but Is Required for the Cytotoxic Function of NK Cells
Vicioso Y, Wong DP, Roy NK, Das N, Zhang K, Ramakrishnan P, Parameswaran R Frontiers in Immunology. 2021.
Vaccines & Infectious Disease
Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19
Szabo PA, Dogra P, Gray JI, Wells SB, Connors TJ, Weisberg SP, Krupska I, Matsumoto R, Poon M ML, Idzikowski E, Morris SE, Pasin C, Yates AJ, Ku A, Chait M, Davis-Porada J, Guo XV, Zhou J, Steinle M, Mackay S, Saqi A, Baldwin MR, Sims PA, Farber DL Immunity. 2021.
Cellular and Regenerative Medicine
Mesenchymal stromal cell delivery of oncolytic immunotherapy improves CAR-T cell antitumor activity
McKenna MK, Englisch A, Brenner B, Smith T, Hoyos V, Suzuki M, Brenner MK Molecular Therapy. 2021.
Oncology
Use of Multi-Site Radiation Therapy for Systemic Disease Control
Patel RR, Verma V, Barsoumian HB, Ning MS, Chun SG, Tang C, Chang JY, Lee PP, Gandhi S, Balter P, Dunn JD, Chen D, Puebla-Osorio N, Cortez MA, Welsh JW International Journal of Radiation Oncology*Biology*Physics. 2021.
Cellular and Regenerative Medicine
Complement‐activated human endothelial cells stimulate increased polyfunctionality in alloreactive T cells
Xie CB, Zhou J, Mackay S, and Pober JS. American Journal of Transplantation. 2021.
Vaccines & Infectious Disease
Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
Su Y, Chen D, Yuan D, Lausted C, Choi J, Dai CL, Voillet V, Duvvuri VR, Scherler K, Troisch P, Baloni P, Qin G, Smith B, Kornilov SA, Rostomily C, Xu A, Li J, Dong S, Rothchild A, Zhou J, Murray K, Edmark R, Hong S, Heath J, Earls J, Zhang R, Xie J, Li S, Roper R, Jones L, Zhou Y, Rowen L, Liu R, Mackay S, O'Mahony DS, Dale CR, Wallick JA, Algren HA, Michael ZA, the ISB-Swedish COVID19 Biobanking Unit, Wei W, Price ND, Huang S, Subramanian N, Wang K, Magis AT, Hadlock J, Hood L, Aderem A, Bluestone JA, Lanier LL, Greenberg PD, Gottardo R, Davis MM, Goldman JD, and Heath JR. Cell . 2020.
Cancer Immunology
Progression-free Survival and Biomarker Correlates of Response With BEMPEG Plus NIVO in Previously Untreated Patients With Metastatic Melanoma: Results From The PIVOT-02 Study
Diab A, Tykodi SS, Daniels GA, Maio M, Curti BD, Lewis KD, Jang S, Kalinka E, Puzanov I, Spira AI, Cho DC, Guan S, Puente E, Hoch U, Currie SL, Nguyen T, Lin W, Tagliaferri MA, Zalevsky J, Sznol M, Hurwitz ME SITC. 2020.
Cancer Immunology
Changes in peripheral and local tumor immunity after neoadjuvant chemotherapy reshape clinical outcomes in patients with breast cancer
Axelrod ML, Nixon ML, Gonzalez-Ericsson PI, Bergman RE, Pilkinton MA, McDonnell WJ, Sanchez V, Opalenik S, Loi S, Zhou J, Mackay S, Rexer BN, Abramson VG, Jansen VM, Mallal SA, Donaldson J, Tolaney SM, Krop I, Garrido-Castro AC, Marotti JD, Shee K, Miller TW, Sanders M, Mayer IA, Salgado R, and Balko JM. Clinical Cancer Research. 2020.
Cancer Immunology
Targeted Co-delivery of Tumor Antigen and α-Galactosylceramide to CD141+ Dendritic Cells Induces a Potent Tumor Antigen-Specific Human CD8+ T Cell Response in Human Immune System Mice
Huang J, Zhou J, Ghinnagow R, Seki T, Iketani S, Soulard D, Paczkowski P, Tsuji Y, Mackay S, Cruz LJ, Trottein F, and Tsuji M. Frontiers in Immunology. 2020.
Inflammation & Neurology, Vaccines & Infectious Disease
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19
Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Aoun Barakat BMC Neurology. 2020.
Cellular and Regenerative Medicine
Metabolic Reprograming via Deletion of CISH in Human iPSC-Derived NK Cells Promotes In Vivo Persistence and Enhances Anti-tumor Activity
Zhu H, Blum RH, Bernareggi D, Ask EH, Wu Z, Hoel HJ, Meng Z, Wu C, Guan K-L, and Kaufman DS. Cell Stem Cell. 2020.
Cancer Immunology
Multi-omic single-cell snapshots reveal multiple independent trajectories to drug tolerance in a melanoma cell line
Su Y, Ko ME, Cheng H, Zhu R, Xue M, Wang J, Lee JW, Frankiw L, Xu A, Wong S, Robert L, Takata K, Yuan D, Lu Y, Huang S, Ribas A, Levine R, Nolan GP, Wei W, Plevritis SK, Li G, Baltimore D, and Heath JR. Nature Communications. 2020.
Cellular and Regenerative Medicine
CAR T-cells that target acute B-lineage leukemia irrespective of CD19 expression
Fousek K, Watanabe J, Joseph SK, George A, An X, Byrd TT, Morris JS, Luong A, Martinez-Paniagua MA, Sanber K, Navai SA, Gad AZ, Salsman VS, Mathew PR, Kim HN, Wagner DL, Brunetti L, Jang A, Baker ML, Varadarajan N, Hegde M, Kim Y-M, Heisterkamp N, Abdel-Azim H, and Ahmed N. Leukemia. 2020.
Cellular and Regenerative Medicine
Advanced Cell Mapping Visualizations for Single Cell Functional Proteomics Enabling Patient Stratification
Bowman N, Liu D, Paczkowski P, Chen J, Rossi J, Mackay S, Bot A, and Zhou J. Proteomics. 2020.
Cellular and Regenerative Medicine
Persistent Polyfunctional Chimeric Antigen Receptor T Cells That Target Glypican 3 Eliminate Orthotopic Hepatocellular Carcinomas in Mice
Li D, Li N, Zhang YF, Fu H, Feng M, Schneider D, Su L, Wu X, Zhou J, Mackay S, Kramer J, Duan Z, Yang H, Kolluri A, Hummer AM, Torres MB, Zhu H, Hall MD, Luo X, Chen J, Wang Q, Abate-Daga D, Dropublic B, Hewitt SM, Orentas RJ, Greten TF, and Ho M. Gastroenterology. 2020.
Cancer Immunology
Persistence of adoptively transferred T cells with a kinetically engineered IL-2 receptor agonist
Parisi G, Saco JD, Salazar FB, Tsoi J, Krystofinski P, Puig-Saus C, Zhang R, Zhou J, Cheung-Lau GC, Garcia AJ, Grasso CS, Tavare R, Hu-Lieskovan S, Mackay S, Zalevsky J, Bernatchez C, Diab A, Wu AM, Comin-Anduix B, Charych D, and Ribas A. Nature Communications. 2020.
Cancer Immunology
SIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma
Chen Y-P, Kim HJ, Wu H, Price-Troska T, Villasboas JC, Jalali S, Feldman AL, Novak AJ, Yang, Z-Z, and Ansell SM. Blood Cancer Journal. 2019.
Cellular and Regenerative Medicine
Rational design of a trimeric APRIL-based CAR-binding domain enables efficient targeting of multiple myeloma
Schmidts A, Ormhoj M, Choi BD, Taylor AO, Bouffard AA, Scarfo I, Larson RC, Frigault MJ, Gallagher K, Castano AP, Riley LS, Cabral ML, Boroughs AC, Velasco Cardenas RM-H, Schamel W, Zhou J, Mackay S, Tai Y-T, Anderson KC, Maus MV. Blood Advances. 2019.
Cancer Immunology
Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs
Xiao Y, Liu C, Blatchley MR, Kim D, Zhou J, Xu M, Gerecht S, and Fan R. Advanced Biosystems. 2019.
Cancer Immunology
Translational Single Cell Proteomics Profiling of Live T-Lymphocytes in Oncogene-Addictive NSCLC under Immune Checkpoint Inhibitor (CPI) Treatment
Lim ZF, Wu X, Hafez M, Albandar H, Zhu L, Yang H, Mackay S, Chen J, Zhou J, and Ma PC. Presented at TRCCC. 2019.
Cancer Immunology
Polyfunctionality determined by single-cell proteomics of bone marrow-derived CD4 T cells from patients with acute myeloid leukemia identifies patients responding to anti-PD-1-based therapy and discovers profound T cell defect in mutant TP53 disease.
Daver N, Kantarjian H, Mackay S, Flynn B, Basu S, Garcia-Manero G, Alfayez M, Konopleva M, Matthews J, Kornblau S, Jabbour E, Zhou J, Andreeff M; IsoPlexis, Branford, CT. Presented at the AACR Conference. 2019.
Cancer Immunology
Triple checkpoint blockade targeting PD-1, TIM-3, and LAG-3 reinvigorates ovarian cancer-infiltrating T cells by increasing T cell polyfunctionality and effector function
Kaufmann JK, Flynn B, Morse K, Speranza MC, Zhou J, Ramaswamy S, Mackay S, and Coleman KG. Presented at AACR Annual Meeting. 2019.
Cellular and Regenerative Medicine
NeoTCR-P1, a novel neoepitope-specific adoptive cell therapy, consists of T cells with ‘younger’ phenotypes that rapidly proliferate and kill target cells upon recognition of cognate antigen
Sennino B, Conroy A, Purandare B, Litterman A, Jacoby K, Moot R, Lu W, Nguyen D, Urbinati F, Foy S, Hunter T, Dalmas O, Bethune M, Park T, Peng S, Franzusoff A, and Mandi S. Presented at AACR Annual Meeting. 2019.
Cancer Immunology, Cellular and Regenerative Medicine
Single-Cell Multiplexed Proteomics on the IsoLight Resolves Cellular Functional Heterogeneity to Reveal Clinical Responses of Cancer Patients to Immunotherapies
Liu D, Paczkowski P, Mackay S, Ng Colin, and Zhou J. Biomarkers for Immunotherapy of Cancer - Springer. 2019.
Cellular and Regenerative Medicine
Aged CAR T cells exhibit enhanced cytotoxicity and effector function but shorter persistence and less memory-like phenotypes.
Kotani H, Li Gongbo, Yao Jiqiang, Mesa TE, Chen J, Boucher JC, Yoder SJ, Zhou J, Davila ML. Presented at ASH Annual Meeting. 2018.
Cellular and Regenerative Medicine
Notch Activation Rescues Exhaustion in CISH-Deleted Human iPSC-Derived Natural Killer Cells to Promote In Vivo Persistence and Enhance Anti-Tumor Activity
Zhu H, Blum R, Wu Z, Bahena A, Hoel HJ, Ask EH, Guan K-L, Malmberg K-J, and Kaufman DS. Presented at ASH. 2018.
Cellular and Regenerative Medicine
 Abbreviated T-cell activation on the automatic CliniMACS Prodigy device enhances bispecific CD19/22 Chimeric Antigen Receptor T-cell viability and fold expansion, reducing total culture duration.
Srivastava SK, Panch SR, Jin J, Shalabi H, Shah NN, Flynn B, Zhou J, Mackay S, Highfill SL, Stroncek DF. Presented at ASH Annual Meeting.. 2018.
Cancer Immunology
 Single-cell proteomic analysis of T cells stimulated by Bi-specific T cell Engagers shows a robust and unique polyfunctional secretion profile.
Mackay S, Paczkowski P, Flynn B, Morse K, Liu D, Coupet TA, Godbersen C, Sentman CL, Zhou J. Presented at ASH Annual Meeting.. 2018.
Cellular and Regenerative Medicine
 Improving T cell functionality for adoptive T cell therapy in metastatic colon cancer.
Ravindranathan S, Jajja MR, Petersen C, Bommireddy R, Selvaraj P, Yang L, El-Rayes B, Flynn B, Waller EK. Presented at ASH Annual Meeting.. 2018.
Cancer Immunology
 Single-cell PSI of CD8+ TILs in melanoma shows uniquely sensitive correlates with response to anti-PD-1/CTLA4 therapy, where histology and serum cytokines were unable to detect significant associations.
Mackay S, Flynn B, Morse K, Paczkowski P, Chen J, Liu D, Bacchiocchi A, Heath JR, Fan R, Sznol M, Halaban R, Zhou J. Presented at ASH Annual Meeting.. 2018.
Cancer Immunology
 Single-Cell Polyfunctionality of CD4+ T Cells Shows Promise as a Predictor of Overall Survival of Pancreatic Cancer Patients Treated with GVAX Vaccine.
Mackay S, Flynn B, Chen J, Paczkowski P, Jaffee E, Zheng L, and Zhou J. Presented at FOCiS.. 2018.
Cancer Immunology
 Single-Cell Highly Multiplexed Proteomics Identifies Novel Polyfunctional Human CD8+ T Cell Signatures Induced by a Nanoparticle-Based Melanoma Vaccine in Human Immune System Mice.
Mackay S, Morse K, Paczkowski P, Huang J, Tsuji M, and Zhou J. Presented at FOCiS.. 2018.
Cellular and Regenerative Medicine
 Preinfusion Polyfunctional Anti-CD19 Chimeric Antigen Receptor T Cells Associate with Clinical Outcomes in NHL.
Rossi J, Paczkowski P, Shen Y, Morse K, Flynn B, Kaiser A, Ng C, Gallatin K, Cain T, Fan R, Mackay S, Heath JR, Rosenberg SA, Kochenderfer JN, Zhou J, and Bot A. Blood.. 2018.
Cellular and Regenerative Medicine
 Enhanced Expansion and Tumor Targeting of Adoptively Transferred T Cells with NKTR-214.
Parisi G, Saco J, Salazar F, Krystofinski P, Tsoi J, Zhang R, Puig Saus C, Zhou J, Hu-Lieskovan S, Comin-Anduix B, Wu A, Charych DH, Ribas A. Session PO.CL06.03 - Adoptive Cell Therapy 3. American Association for Cancer Research Annual Meeting .. 2018.
Cancer Immunology
 Single-Cell Cytokine Profiling of Tumor-Infiltrating T Cells to Measure Patient Responses to Anti-PD-1 Therapy.
Mackay S, Flynn B, Morse K, Paczkowski P, Bacchiocchi A, Heath JR, Fan R, Halaban R, and Zhou J. Presented at TRCCC Annual Meeting.. 2018.
Cancer Immunology
 Intratumoral (IT) injection of the toll-like receptor 4 (TLR4) agonist G100 induces a clinical response and a T cell response locally and systemically.
Seo YD, Zhou J, Morse K, Patino J, Mackay S, Kim EY, Conrad III EU, O'Malley RB, Cranmer L, Lu H, Hsu FJ, Xu Y, Loggers E, Hain T, Pillarisetty VG, Kane G, Riddell S, Meulen J, Jones RL, Pollack SM. Journal of Clinical Oncology, 36, Suppl 5S.. 2018.
Cellular and Regenerative Medicine
 A Kinetic Investigation of Interacting, Stimulated T Cells Identifies Conditions for Rapid Functional Enhancement, Minimal Phenotype Differentiation, and Improved Adoptive Cell Transfer Tumor Eradication.
Zhou J, Bethune MT, Malkova N, Sutherland AM, Begonya CA, Su Y, Baltimore D, Ribas A, and Heath JR. PLoS One 13 (1).. 2018.
Inflammation & Neurology
 Enhanced TLR2 Responses in Multiple Sclerosis.
Fujiwara M, Anstadt EJ, Flynn B, Morse K, Ng C, Paczkowski P, Zhou J, Mackay S, Wasko N, Nichols F, Clark RB. Clinical and Experimental Immunology.. 2018.
Inflammation & Neurology
Novel Technologies to Query Single Cells in Hematopoiesis.
Fan R, Satija R Presented at the ASH Annual Meeting. 2017.
Cellular and Regenerative Medicine
 Identification of Functional Determinants of Response and Resistance to CD19 Chimeric Antigen Receptor (CAR) T-Cell Therapy of Chronic Lymphocytic Leukemia.
Fraietta JA, Lacey SF, Orlando E, Pruteanu J, Gohil M, Wang Y, Boesteanu A, O'Connor R, Ambrose DE, Hwang WT, Wilcox N, Bedoya F, Dorfmeier C, Chen F, Parakandi H, Gupta M, Pequignot E, Johnson FB, Kulikovskaya I, Liu L, Lundh SM, Xu J, Davis MM, Young RM, Levine BL, Siegel DL, Huang A, Wherry EJ, Zhou J, Paczkowski P, Mackay S, Brogdon J, Bitter H, Porter DL, June CH, and Melenhorst JJ. Blood 130 (Suppl. 1) 3181 .. 2017.
Cellular and Regenerative Medicine
 Single-Cell Multiplex Proteomics Reveals Synergistic Impact of Antigen and Rimiducid-Dependent Stimulatory Signals on Promoting Polyfunctional GoCAR-T cells Targeting Prostate Stem Cell Antigen (PSCA).
Mackay S, Flynn B, Morse K, Ng C, Paczkowski P, Mahendravada A, Shinners N, Spencer D, Foster A, and Zhou J. Blood 130 (Suppl. 1) 2281.. 2017.
Cellular and Regenerative Medicine
 Single-Cell Multiplexed Cytokine Profiling of CD19 CAR-T Cells Reveals a Diverse Landscape of Polyfunctional Antigen-Specific Response.
Xue Q, Bettini E, Paczkowski P, Ng C, Kaiser A, McConnell T, Kodrasi O, Quigley M, Heath JR, Fan R, Mackay S, Dudley M, Kassim S, and Zhou J. Journal for ImmunoTherapy of Cancer. 5:85.. 2017.
Cellular and Regenerative Medicine
 Single-Cell Proteomic Assessment of CD19 CAR-T Cells Reveals a Complex Landscape of Polyfunctional Antigen-Specific Response.
Xue Q, Bettini E, Paczkowski P, Ng C, Kaiser A, McConnell T, Kodrasi O, Quigley M, Heath JR, Fan R, Mackay S, Dudley M, Kassim S, and Zhou J. Presented at FOCiS.. 2017.
Cellular and Regenerative Medicine
 Polyfunctional Anti-CD19 CAR T Cells Determined by Single-Cell Multiplex Proteomics Associated with Clinical Activity in Patients with Advanced Non-Hodgkin’s Lymphoma.
Rossi J, Paczkowski P, Shen Y, Morse K, Flynn B, Kaiser A, Ng C, Gallatin K, Cain T, Fan R, Mackay S, Heath JR, Rosenberg SA, Kochenderfer JN, Zhou J, and Bot A. Proc. AACR Annual Meeting 177 (13 Suppl.) 2990.. 2017.
Cellular and Regenerative Medicine
 Single-Cell Cytokine Profiling of Tumor-Infiltrating T Cells to Measure Patient Responses to Anti-PD-1 Therapy.
Mackay S, Flynn B, Morse K, Paczkowski P, Bacchiocchi A, Fan R, Halaban R, and Zhou J. Journal of Clinical Oncology, 35 (9), Suppl.. 2017.
Oncology
 Single-Cell Analysis Resolves the Cell State Transition and Signaling Dynamics Associated with Melanoma Drug-Induced Resistance.
Su Y, Wei W, Robert L, Xue M, Tsoi J, Garcia-Diaz A, Homet Moreno B, Kim J, Ng R, Lee JW, Koya RC, Comin-Anduix B, Graeber TG, Ribas A, and Heath JR. Proc. Natl. Acad. Sci.. 2017.
Oncology
 Synergistic IL-6 and IL-8 Paracrine Signalling Pathway Infers a Strategy to Inhibit Tumour Cell Migration.
Jayatilaka H, Tyle P, Chen J, Kwak M, Ju J, Kim HJ, Lee JSH, Wu PH, Gilkes DM, Fan R, and Wirtz D. Nature Communications, 8, 15584.. 2017.
Vaccines & Infectious Disease
 CD8+ T-Cell Mediated Anti-Malaria Protection Induced by Malaria Vaccines; Assessment of Hepatic CD8+ T Cells by SCBC Assay.
Zhou J, Kaiser A, Ng C, Karcher R, McConnell T, Paczkowski P, Fernandez C, Zhang M, Mackay S, and Tsuji M. Human Vaccines & Immunotherapeutics, 13 (7), 1625-1629.. 2017.
Cellular and Regenerative Medicine
 Novel Multiplexing Technologies for Comprehensive Functional Characterizations of CAR-T Final Products.
Xue Q, Bettini E, Paczkowski P, Ng C, Kaiser A, McConnell T, Kodrasi O, Quigley M, Heath JR, Fan R, Mackay S, Dudley M, Kassim SH, and Zhou J. Presented at BioMAN Workshop 2016.. 2016.
Oncology
 Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted Combination Therapy in Glioblastoma.
Wei W, Shin YS, Xue M, Matsutani T, Masui K, Yang H, Ikegami S, Gu Y, Herrmann K, Johnson D, Ding X, Hwang K, Kim J, Zhou J, Su Y, Li X, Bonetti B, Chopra R, James CD, Cavenee WK, Cloughesy TF, Mischel PS, Heath JR, and Gini B. Cancer Cell, 29:4 563-573.. 2016.
Oncology
 Critical Points in Tumorigenesis: A Carcinogen-Initiated Phase Transition Analyzed via Single-Cell Proteomics.
Poovathingal SK, Kravchenko-Balasha N, Shin YS, Levine RD, and Heath JR. Small, 12 (11), 1613-6829.. 2016.
Oncology
 Supramolecular Probes for Assessing Glutamine Uptake Enable Semi-Quantitative Metabolic Models in Single Cells.
Xue M, Wei W, Su Y, Johnson D, and Heath JR. Journal of the American Chemical Society, 138 (9), 3085-3093.. 2016.
 Single-Cell Analysis Tools for Drug Discovery and Development.
Heath JR, Ribas A, and Mischel PS. Nature Reviews Drug Discovery, 15, 204-216.. 2016.
Oncology
 JAK-STAT Pathway Activation in Malignant and Non-Malignant Cells Contributes to MPN Pathogenesis and Therapeutic Response.
Kleppe M, Kwak M, Koppikar P, Riester M, Keller M, Bastian L, Hricik T, Bhagwat N, Abdel-Wahab OI, Marubayashi S, Chen JJ, Romanet V, Fridman JS, Bromberg J, Murakami M, Radimerski T, Michor F, Fan R, and Levine RL. Cancer Discovery, 5 (3), 316-31.. 2015.
Vaccines & Infectious Disease
 Analysis of Single-Cell Secretion Reveals a Role for Paracrine Signaling in Coordinating Macrophage Response to TLR4 Stimulation.
Xue Q, Lu Y, Eisele MR, Sulistijo E, Fan R, and Miller-Jensen K. Science Signaling, 8, 381.. 2015.
Oncology
 Chemical Methods for the Simultaneous Quantitation of Metabolites and Proteins from Single Cells.
Xue M, Wei W, Su Y, Kim J, Shin YS, Mai WX, Nathanson DA, and Heath JR. Journal of the American Chemical Society, 137 (12), 4066–4069.. 2015.
Vaccines & Infectious Disease
 Highly Multiplexed Profiling of Immune Effector Functions Reveals Deep Functional Heterogeneity in Response to Pathogenic Ligands.
Lu Y, Xue Q, Eisele MR, Sulistijo E, Brower K, Han L, Amir ED, Pe’er D, Miller-Jensen K, and Fan R. Proc. Natl. Acad. Sci., 112 (7), 607-615.. 2015.
Oncology
 Glioblastoma Cellular Architectures are Predicted Through the Characterization Of Two-Cell Interactions.
Kravchenko-Balasha N, Wang J, Remacle F, Levine RD, and Heath JR. Proc. Natl. Acad. Sci., 111, 6521- 26.. 2014.
Inflammation & Neurology
 Human NK Cells Licensed by Killer Ig Receptor Genes have an Altered Cytokine Program that Modifies CD4+ T Cell Function.
Lin L, Ma C, Wei B, Aziz N, Rajalingam R, Yusung S, Erlich HA, Trachtenberg EA, Targan SR, McGovern DPB, Heath JR, and Braun J. Journal of Immunology, 193, 940-9.. 2014.
Vaccines & Infectious Disease
 Conversion of Danger Signals into Cytokine Signals by Hematopoietic Stem and Progenitor Cells for Regulation of Stress-Induced Hematopoiesis.
Zhao JL, Ma C, O'Connell RM, Mehta A, Diloreto R, Heath JR, and Baltimore D. Cell Stem Cell, 14(4), 445-459.. 2014.
Oncology
 A Microchip Platform for Interrogating Tumor-Macrophage Paracrine Signaling at the Single-Cell Level.
Elitas M, Brower K, Lu Y, Chen JJ, and Fan R. Lab on a Chip, 14, 3582.. 2014.
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