Vaccine Stratification and Monitoring
Solutions Accelerated by IsoPlexis
- Vaccines & Immunology
Apply PSI as correlates to cancer vaccine patient survival and outcome
Discover biomarkers of response by uncovering functional immune cell subsets which correlate to outcome.
Identify enhanced polyfunctionality and PSI in after cancer vaccine treatment
IsoPlexis stratifies higher response rates based on PSI
Upregulation of Polyfunctional strength ratio (PSR) was correlative to overall survival
GVAX vaccination enhances polyfunctionality and PSI in CD4+ T cells of patients with pancreatic cancer. Polyfunctional CD4+ T cells were evaluated by 24-hour stimulation of anti-CD3/CD28.
An average increase of polyfunctional CD4+ T cells was detected in patients after GVAX treatment. The upregulated PSI of CD4+ T cells by the vaccine was predominated by effector proteins that are associated with antitumor immunity including Granzyme B, IFN-g, MIP-1a and TNF-b. The data was averaged from 5 patients.1