Humanized Mouse Vaccines
Identify polyfunctional differences within the development of combination cancer vaccines1
Leverage the power of polyfunctional immune cell analysis to accelerate vaccine development.
Identify differences in combination vaccine structures resulting from tumor vaccine activation
PSI revealed differences for more accurate evaluation of tumor vaccine efficacy in a preclinical setting
Nanoparticle vaccine containing tumor antigens can efficiently activate CD8+ T cells and induce polyfunctional CD8+ T cells that are associated with antitumor activity
Single-Cell CD8+ polyfunctionality and PSI are upregulated in NP-vaccinated mouse group relative to Naïve controls. A robust upregulation of polyfunctional (secreting multiple cytokines) human CD8+ T cells in HIS mice immunized with NP/Antigen/Ab was observed, compared to other groups of HIS mice.
We observed a statistically significant difference between the NP/Antigen/Ab group and both the Naïve and Antigen groups. The enhanced PSI was predominated by effector proteins.