Targeting Autoimmune Progression

Solutions Accelerated by IsoPlexis

  • Systemic Lupus Progression

T Cell polyfunctional subsets in SLE determine contribution to pathogenesis and potential targets1

Uncover the functional immune subsets which drive progression in autoimmune diseases.

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Research Area

Development Stage

Discovery

Goal

Identify differences & mechanism in the expanded T cell populations within autoimmune disease

How our Award-Winning IsoLight Single-Cell System is Making a Difference

polyfunctional cell

Solution

Polyfunctionality reveals key Tfh subsets that lead to disease progression in SLE

polyfunctional cell

Finding

SLE patients exhibit polyfunctional Tfh with B-helper cytokine IL-21 and effector cytokines IL-2, IFNγ and TNFα, indicating potential therapeutic targets based on source of disease progression

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Follow Our Data

See the latest published data in Inflammatory & Autoimmune Disease

Polyfunctional cTFH cells as detected on the IsoCode, indicating healthy versus SLE patient differences and potential early stage biomarkers. The expanded population in SLE is polyfunctional and produces elevated levels of B-helper cytokine IL-21 and effector cytokines IL-2, IFN-γ and TNF-α.

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Tfh Polyfunctionality

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