Predictive Biomarkers for Allograft Rejection

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  • Allograft Rejection Prediction

Apply PSI to inflammation in chronic allograft rejection

Uncover the biomarkers of inflammation that correspond with allogeneic T cell mediated injury

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Research Area

Development Stage



Identify mechanisms of inflammation in chronic allograft rejection

How our Award-Winning IsoLight Single-Cell System is Making a Difference

polyfunctional cell


Polyfunctional profiles reveal differences in CD4+ and CD8+ Tem cell clones

polyfunctional cell


Activated T cell clones showed enhanced polyfunctionality

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See the latest published data in Inflammatory & Autoimmune Disease

  • Identify enhanced polyfunctionality of alloreactive CD4+ and CD8+ effector memory T cells (Tem) that play an important role in chronic allograft rejection.
  • Identify the correlation of high polyfunctionality of Tem to alloreactivity induced by allogeneic human endothelial cells (ECs).
  • Demonstrate panel reactive antibody (PRA) -treated ECs can promote the formation of highly polyfunctional Tem that may accelerate chronic allograft rejection.
  • Reveal the impact of highly polyfunctional Tem on allograft rejection and their potential for patient monitoring before and after organ transplantation.

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[Ref: Xie et al. Human endothelial cells activated by complement membrane attack complexes differentially affect allogeneic CD4 and CD8 responses. Presented at Human and Translational Immunology 2019]

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