Stratification and Monitoring

Solutions Accelerated by IsoPlexis

  • Cancer Immunology

Apply TILs PSI as a correlate to response in combination checkpoint therapy1

Uncover the polyfunctional immune cell subsets which correlate to in vivo activity and help drive biomarker correlates to response.

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Research Area

Development Stage



Find correlates to in vivo patient response in combination checkpoint therapy (Ipi & Nivo)

How our Award-Winning IsoLight Single-Cell System is Making a Difference

polyfunctional cell


IsoPlexis’ PSI successfully stratifies patient responders and non-responders

polyfunctional cell


Polyfunctional strength uniquely correlated with response, while histology and serum cytokine measurements did not

follow our data

Follow Our Data

See the latest published data in Checkpoint & Combination Immunotherapies

Single cell polyfunctionality shows positive correlation with clinical anti-tumor responses after treatment. Samples from responders have 9x more polyfunctional cells than non-responders, and 40x higher polyfunctional strength (p= 0.0294).

Individual cells secreted various combinations of effector cytokines (Granzyme B, IFN-γ, MIP-1α, Perforin and TNF-α) associated with anti-tumor immunity.

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Polyfunctional Strength


Detect Critical Differences

PSI as a biomarker outperformed other measured metrics. Single-Cell PSI of CD8+ TILs significantly correlates with outcome of anti-PD-1/CTLA4 treated patients with metastatic melanoma.

No significant association was identified between clinical outcome and other measurements, including TILs % by histopathological assessment or serum concentration.1

PSI, % TILs, Cytokine Concentration

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