Case Study: Inhibitory Mechanism of Monocytes Towards Immune Suppression in Follicular Lymphoma

Solutions Accelerated by IsoPlexis

  • Follicular Lymphoma

Pre-clinical Choice Metric

Apply the power of polyfunctional strength to identify functional immune cell subsets which correlate with in vivo activity.

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Research Area

Development Stage

Pre-clinical

Goal

Reveal mechanism in Follicular Lymphoma

How our Award-Winning IsoLight Single-Cell System is Making a Difference

polyfunctional cell

Solution

CD14+SIRPαhi (signal regulatory protein-α) monocytes/macrophages were associated with an inferior survival in FL, & increased numbers of the CD14−SIRPα low subset appeared to correlate with a better survival.

polyfunctional cell

Finding

Cellular IL-10 level shows critical mechanistic importance of monocyte function in the interaction with T-cell functional response, which correlated with patients who had inferior survival.

follow our data

Follow Our Data

See the latest published data in Cancer Immunology Research

Revealed an inhibitory mechanism of enhanced IL-10 in single-cell polyfunctional CD14+ SIRPαHi subsets reducing T cell proliferation, which provides the functional insights of Mo/MΦs subset for FL patients, which were implicated in inferior survival of patients.

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