Case Study: Inhibitory Mechanism of Monocytes Towards Immune Suppression in Follicular Lymphoma
Solutions Accelerated by IsoPlexis
- Follicular Lymphoma
Pre-clinical Choice Metric
Apply the power of polyfunctional strength to identify functional immune cell subsets which correlate with in vivo activity.
Reveal mechanism in Follicular Lymphoma
CD14+SIRPαhi (signal regulatory protein-α) monocytes/macrophages were associated with an inferior survival in FL, & increased numbers of the CD14−SIRPα low subset appeared to correlate with a better survival.
Cellular IL-10 level shows critical mechanistic importance of monocyte function in the interaction with T-cell functional response, which correlated with patients who had inferior survival.