Cell Therapeutic Discovery Research

Solutions & Cell Therapy Types Accelerated by IsoPlexis

  • NK Cell Therapy

Make decisions preclinically, when comparing subtle gene edits in NK cell therapies1

Discover the true function of engineered cell products and the functional subsets that make a difference.

Download EBook

Research Area

Development Stage

Discovery

Goal

Reveal choice in NK cell therapy by identifying differences resulting from subtle gene edits

How our Award-Winning IsoLight Single-Cell System is Making a Difference

polyfunctional cell

Solution

PSI™ revealed potency differences in gene edited NK cell therapies to enhance decision making

polyfunctional cell

Finding

These critical potency differences between edited and wildtype cells also correlated with in vivo mouse response to therapy

follow our data

Follow Our Data

See the latest published data in Cell Therapeutic Discovery Research

Polyfunctionality and PSI underscore significant differences between gene-edited KO- iPSC-NK cells and wild type cells. The CISH-/- knock- out cells showed enrichment of polyfunctional cell subsets compared to the wild type samples.

Similarly, the PSI of the knock-out cells is substantially (10x) higher than of the wild type (right) indicating that CIS plays a key role in regulating NK cell activation-induced exhaustion and that Notch activation prevents this exhaustion and enables production of functionally hyperactive NK cells. At day 35, CISH-/- iPSC-NK demonstrate better anti-tumor activity in vivo. These results are consistent with 10x higher in vitro PSI of CISH KO-iPSC-NK cells relative to wild type cells.1

Download EBook
PSI

Request a Seminar

Request a Seminar
Discover IsoLight