Research Area: Solid tumor & oncology
Development Stage: Prediction
Goal: Find correlates to in vivo patient response in combination checkpoint therapy (Ipi & Nivo)
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Single cell polyfunctionality shows positive correlation with clinical anti-tumor responses after treatment. Samples from responders have 9x more polyfunctional cells than non-responders, and 40x higher polyfunctional strength (p= 0.0294).
Individual cells secreted various combinations of effector cytokines (Granzyme B, IFN-γ, MIP-1α, Perforin and TNF-α) associated with anti-tumor immunity.1
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PSI as a biomarker outperformed other measured metrics. Single-Cell PSI of CD8+ TILs significantly correlates with outcome of anti-PD-1/CTLA4 treated patients with metastatic melanoma.
No significant association was identified between clinical outcome and other measurements, including TILs % by histopathological assessment or serum concentration.1