Follow the Data: Applying PSI to CAR T-cell product release, in a way that correlates to in vivo activity1

Research Area: Cell engineering & therapy

Development Stage: Prediction

Goal: Identify pre-infusion correlates to in vivo active of cell therapy and patient outcome

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How our single-cell systems are making a difference

Solution:  IsoPlexis' PSI is able to stratify responders and non-responders

Finding: Polyfunctional strength was found to correlate with objective response to CAR-T cell therapy, where other pre-infusion metrics did not

Follow the data

PSI of the pre-infusion CAR-T cell products showed significant correlation with the objective response of patients. The PSI, measured across a cohort of 20 patients, combined the CD4+ and CD8+ CAR-T response to CD19-K562 stimulation.

The average PSI of the responder subgroup was more than twice as high as the PSI of the non-responders, a difference that was shown to be statistically significant (p = 0.0119).1

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IsoPlexis finds critical differences

PSI outperformed other pre-infusion metrics, including IFN-g co-culture cytokine intensity, ratio of CD4+ to CD8+ T cells, and various T cell phenotype frequencies.

PSI was the only metric that statistically differentiated responding from non-responding patients. The correlation of PSI with clinical outcome indicates the metric’s potential as a biomarker for guiding personalized CAR-T cell treatments and predicting therapeutic efficacy.1

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