Research Area: Vaccines & immunology research
Development Stage: Optimization
Goal: Identify differences in polyfunctionality with different vaccine structures
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Single-cell functional heat map shows unique and highly polyfunctional hepatic CD8+ T-cell subsets, which were induced in a group of mice that received IrPySpz immunization and live PySpz challenge. A fewer percentage of hepatic CD8+ T cells with high polyfunctionality was induced in either naïve mice or IrNSG-immunized mice (which did not confer protection).
These results demonstrate that a group of polyfunctional hepatic CD8+ T cells, having both effector and chemo-attractive functions at a single cell level, may associate with anti-malaria immunity. The multiple markers, which were unique to hepatic CD8+ T cells derived from IrSpz-immunized and partially protected mice, are identified as a co-secretion of MIP-1α, RANTES, IFN-γ, and/or IL-17A, from a single hepatic CD8+ T cell.1
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