Cancer cells constantly evolve, regularly adopting new states in response to acute and chronic stimuli, posing a great challenge for treatment, as cells that are initially responsive to pharmacological agents can quickly adopt drug-resistant states through both genetic and non-genetic mechanisms.

Researchers used IsoPlexis’ Single-Cell Proteomics and Single-Cell Metabolomics to show that cancer cell responses to a common stimulus may entail multiple divergent functional pathways while still resulting in the same genomic phenotype.

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