Mesenchymal Stromal Cell Delivery of Oncolytic Immunotherapy Improves CAR-T Cell Anti-tumor Activity

Paper Summary

Mesenchymal Stromal Cell Delivery of Oncolytic Immunotherapy Improves CAR-T Cell Anti-tumor Activity

In a paper published in Molecular Therapy, researchers M. McKenna et al. used IsoPlexis’ Functional Proteomics to show that a combination of immuno-stimulatory CAd-MSCs and CAR-T cells improved T cell effector function, endurance, and infiltration into bulky tumors.

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What's Inside

In this Paper Summary we discuss:

CAd-MSCs stimulate CAR-T cell cytokine production in vitro

CAd-MSCs promote CAR-T cell-mediated tumor reduction in vivo

Highlighting the importance of a multi-pronged approach for superior therapeutic efficacy

Summary_Mesenchymal Stromal Cell Delivery of Oncolytic Immunotherapy Improves CAR-T Cell Anti-tumor Activity_IsoPlexis

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Overcoming Barriers in Adoptive Cell Therapy

The tumor microenvironment (TME) promotes tumor growth and metastasis while suppressing anti-cancer immune responses.

This has proven to be a barrier to adoptive cell therapy. Oncolytic adenoviruses (OAds) can disrupt the TME, thereby restoring and improving immune cell function. However, delivering OAds to solid tumors is challenging.

Researchers from Baylor College of Medicine took a creative approach to this problem by studying how mesenchymal stromal cells (MSCs) can be used to directly deliver two engineered anti-cancer adenoviruses to tumor sites.

Together with CAR-T cell therapy, this approach disrupted the TME, suppressed tumor growth, and encouraged T cell activity.

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