Paper Summary
Key Drivers of Transplant Rejection Identified with Functional Single-Cell Proteomics

In a paper published in the American Journal of Transplantation, Catherine Xie et al. from the Yale University School of Medicine used our highly multiplexed single-cell secreted proteomic analysis to uncover the unique drivers of T cell polyfunctionality, which was found to be driving mixed allograft rejection.

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In this Paper Summary we discuss:
  • Complement and alloantibody-activated ECs trigger altered functions and heterogeneous responders
  • Single-cell proteomics reveals drivers of frequency and polyfunctionality among both CD4+ and CD8+ proliferative effector memory T cells associated with transplant rejection
  • Reducing drivers of polyfunctionality and decreasing markers of transplant rejection

Key Drivers of Transplant Rejection Identified with Functional Single-Cell Proteomics

In a paper published in the American Journal of Transplantation, Catherine Xie et al. from the Yale University School of Medicine used our highly multiplexed single-cell secreted proteomic analysis to uncover the unique drivers of T cell polyfunctionality, which was found to be driving mixed allograft rejection.

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