Key Drivers of Transplant Rejection Identified with Functional Single-Cell Proteomics

Paper Summary

Key Drivers of Transplant Rejection Identified with Functional Single-Cell Proteomics

In a paper published in the American Journal of Transplantation, Catherine Xie et al. from the Yale University School of Medicine used IsoPlexis’ highly multiplexed single-cell secreted proteomic analysis to uncover the unique drivers of T cell polyfunctionality, which was found to be driving mixed allograft rejection.

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What's Inside

In this Paper Summary we discuss:

Complement and alloantibody-activated ECs trigger altered functions and heterogeneous responders

Single-cell proteomics reveals drivers of frequency and polyfunctionality among both CD4+ and CD8+ proliferative effector memory T cells associated with transplant rejection

Reducing drivers of polyfunctionality and decreasing markers of transplant rejection

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A Deeper Look

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Resolving Heterogeneity with IsoPlexis' Singe-Cell Functional Proteomics

Allograft rejection is a complicated process through which immune systems reject a transplanted organ or tissue.

Rejection can be mediated by both cells and antibodies through a process known as mixed rejection, which often results in poor outcomes for patients.

Functional single-cell proteomics resolves this heterogeneity with a highly multiplexed analysis of each cell, allowing researchers to uncover the individual immune cell subpopulations driving mixed rejection.

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