Immune-cell Functional Profiling Sheds Light on the Pathogenesis of Severe COVID-19

Paper Summary

Immune-cell Functional Profiling Sheds Light on the Pathogenesis of Severe COVID-19

In a paper published in Immunity, researchers P. Szabo et al. used IsoPlexis’ Functional Proteomics to indicate that promoting lung-localized immune responses could be a viable alternative vaccination strategy for individuals, such as the immunocompromised or elderly, who are unable to develop effective systemic antibody responses.

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What's Inside

In this Paper Summary we discuss:

The mechanisms behind pathogenic immune responses

An airway-specific cell signature

Airway immune cells work to create a pro-inflammatory environment

A better understanding leads to more effective therapeutic strategies

Summary_Immune-cell Functional Profiling Sheds Light on the Pathogenesis of Severe COVID-19_IsoPlexis

A Deeper Look

More about this Paper Summary

As of April 2021, COVID-19 has resulted in over two million deaths worldwide.

Immune response dysfunction has been implicated in severe COVID-19. However, the precise nature of these pathogenic systemic immune responses remains unclear.

In this study, published in Immunity, researchers used high-dimensional phenotypic, transcriptomic, and functional profiling techniques to identify key disease drivers in patients with severe COVID-19.

The study found evidence for myeloid cell-driven lung inflammation in severe COVID-19 and revealed potential therapeutic targets for reducing lung damage by inhibiting airway-specific inflammatory processes.

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