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Immune response dysfunction has been implicated in severe COVID-19. However, the precise nature of these pathogenic systemic immune responses remains unclear.
In this study, published in Immunity, researchers used high-dimensional phenotypic, transcriptomic, and functional profiling techniques to identify key disease drivers in patients with severe COVID-19.
The study found evidence for myeloid cell-driven lung inflammation in severe COVID-19 and revealed potential therapeutic targets for reducing lung damage by inhibiting airway-specific inflammatory processes.
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