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Identifying Prognostic Biomarkers of Inflammation in COVID-19 with Functional Immune Landscaping

In a paper published in Cell, researchers from the Institute for Systems Biology used IsoPlexis’ Functional Immune Profiling with Single-Cell Proteomics to distinctively reveal the upregulation of polyfunctional monocytes with increasing severity of illness, providing novel insights for COVID-19 pathogenesis and progression.

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What's Inside

In this we discuss:

Functional immune landscaping to map the immune response in COVID-19
Decoding the immune cell response in COVID-19 with functional proteomics
Application of single-cell functional proteomics for novel biomarker discovery
A Deeper Look

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Application of Single-Cell Functional Proteomics for Novel Biomarker Discovery

Functional immune profiling with single-cell proteomics distinctively revealed the upregulation of polyfunctional monocytes with increasing severity of illness, providing novel insights for COVID-19 pathogenesis and progression.

This increase in polyfunctional inflammatory monocytes was likely suppressing T cell function in COVID-19 patients as disease severity increased, which points to a promising therapeutic target for COVID-19 treatment.

These unique insights help accelerate the comprehensive understanding of the immune response by providing potential biomarkers, which are crucial to identifying and developing effective therapeutics.

Download this Paper Summary to learn more!

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