Identifying Prognostic Biomarkers of Inflammation in COVID-19 with Functional Immune Landscaping

Paper Summary

Identifying Prognostic Biomarkers of Inflammation in COVID-19 with Functional Immune Landscaping

In a paper published in Cell, researchers from the Institute for Systems Biology used IsoPlexis’ Functional Immune Profiling with Single-Cell Proteomics to distinctively reveal the upregulation of polyfunctional monocytes with increasing severity of illness, providing novel insights for COVID-19 pathogenesis and progression.

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What's Inside

In this Paper Summary we discuss:

Functional immune landscaping to map the immune response in COVID-19

Decoding the immune cell response in COVID-19 with functional proteomics

Application of single-cell functional proteomics for novel biomarker discovery

Summary_Identifying-prognostic-biomarkers-of-inflammation-in-COVID-19_IsoPlexis

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Application of Single-Cell Functional Proteomics for Novel Biomarker Discovery

Functional immune profiling with single-cell proteomics distinctively revealed the upregulation of polyfunctional monocytes with increasing severity of illness, providing novel insights for COVID-19 pathogenesis and progression.

This increase in polyfunctional inflammatory monocytes was likely suppressing T cell function in COVID-19 patients as disease severity increased, which points to a promising therapeutic target for COVID-19 treatment.

These unique insights help accelerate the comprehensive understanding of the immune response by providing potential biomarkers, which are crucial to identifying and developing effective therapeutics.

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