Identifying Cellular Drivers of Kidney Transplant Rejection with Single-Cell Functional Analysis

In a paper published in the Journal of American Society of Nephrology, researchers used IsoPlexis’ Single-Cell Secretome to characterize TEMRA CD8+ T cell functional properties in kidney transplant recipients.

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What's Inside

In this we discuss:

Characterizing CD8+ T cells
An actionable discovery for future therapeutics
TEMRA CD8+ T cell dysregulation drives kidney transplant rejection
A Deeper Look

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Identifying Cellular Drivers of Kidney Transplant Rejection

Kidney transplantation (KT) is the preferred treatment for patients with end-stage kidney disease, as it is associated with reduced mortality and improved quality of life compared to dialysis.

However, transplant rejection—both acute and chronic—is a major concern. Elevated terminally differentiated effector memory (TEMRA) CD8+ T cell presence and activity, in particular, are linked with elevated risks of kidney dysfunction and transplant failure.

Doan Ngoc and colleagues sought to understand better the relationship between these cells and kidney transplant rejection.

Download this Paper Summary to discover the findings.

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