Functional Proteomic Adaptations Leading to Increased Metastasis

Paper Summary

Functional Proteomic Adaptations Leading to Increased Metastasis

In a study published in Nature Communications, Dr. Denis Wirtz and his team at Johns Hopkins University utilized IsoPlexis’ Functional Proteomics to report synergistic IL-6 and IL-8-mediated signaling pathways directly promote increased cell migration with increasing cell density.

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What's Inside

In this Paper Summary we discuss:

The impact of cytokines and cell density on metastatic behavior

Using functional proteomics to identify soluble factors driving metastasis

New therapeutic target against metastatic cancer cells identified with functional proteomics

Summary_Functional-Proteomic-Adaptations-Leading-to-Increased-Metastasis_IsoPlexis

A Deeper Look

More about this Paper Summary

Understanding What Drives Tumor Spread

As tumors grow, increasing numbers of cancer cells acquire migratory phenotypes, leading to extravasation and metastasis.

The underlying mechanisms promoting metastatic phenotypes are unclear, making it difficult to prevent this adverse behavioral change.

Denis Wirtz at Johns Hopkins University believes that cytokines play a key role in dictating cancer cell phenotypic behavior and is utilizing IsoPlexis’ Functional Proteomics to advance his research.

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