Paper Summary
Functional Proteomic Adaptations Leading to Increased Metastasis

In a study published in Nature Communications, Dr. Denis Wirtz and his team at Johns Hopkins University reported that synergistic IL-6 and IL-8-mediated signaling pathways directly promote increased cell migration with increasing cell density.

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In this Paper Summary we discuss:
  • The impact of cytokines and cell density on metastatic behavior
  • Using functional proteomics to identify soluble factors driving metastasis
  • New therapeutic target against metastatic cancer cells identified with functional proteomics

Functional Proteomic Adaptations Leading to Increased Metastasis

In a study published in Nature Communications, Dr. Denis Wirtz and his team at Johns Hopkins University reported that synergistic IL-6 and IL-8-mediated signaling pathways directly promote increased cell migration with increasing cell density.

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