Employing PSI™ to Identify Optimal Bi-Specific Antibody Candidates

Learn how PSI can help you reveal functional immune-tumor interaction and mechanism of therapy to advise lead choice.

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Application of bispecific antibody constructs to improve immunotherapy success

Recent clinical progress in immunooncology significantly improved clinical outcomes for many patients with hard-to-treat malignant tumors, leading to partial and complete remission and long-term survival in a fraction of patients. However, a large number of patients do not respond to these treatments, creating an urgent need for novel strategies to enhance the efficacy of immunotherapies.

In this Application Note we:
  • Highlight the use of IsoPlexis’ Polyfunctional Strength Index, PSI™, a single-cell cytokinebased metric of cellular potency, in the context of pre-clinical assessment of bispecific antibodies
  • Identify subtle differences in quality of novel bispecific antibody constructs relative to controls, utilizing the PSI of the potent T cell subsets engaged
  • Demonstrate that PSI can improve the choice of lead bispecific immunotherapeutic products by identifying key differences in the therapies’ cytokine-based mechanisms at the single-cell level