Applying Single-Cell Proteomics to Explore Immune Responses in Organ Transplantation

Assessing CD8+ immune responses in kidney transplant patients to reveal functional mechanisms driving humoral rejection.

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What's Inside

In this we discuss:

Polyfunctional cells are important drivers of humoral response in transplant recipients
PSI measurements reflect functional cytokine secretion strength and serve as a useful metric to characterize immune response to transplantation
Identifying upregulated cytokines in cells from patients experiencing humoral response can reveal the mechanistic drivers behind immune rejection
Comparisons between cells from recipients experiencing humoral response versus normal response can reveal specific cytokines that are drivers of immune rejection
Exploring single-cell proteomics in the context of organ transplantation can generate useful hypotheses for mechanistic understanding, patient stratification, patient monitoring, and therapy development
A Deeper Look

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Single-Cell Proteomics in Organ Transplantation

Single-cell proteomics data provides a powerful way to reveal single-cell immune cell functionality in the field of organ transplantation to investigate transplant rejection and mitigation strategies.

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