Integrating Single Cell Functional Proteomics and Transcriptomics

Gain insight into cell behavior by simultaneously capturing transcriptome and IsoPlexis’ unique, predictive functional proteomic data from the same single cell.

Transcriptomics + Functional Proteomics from the Same Cell

Duomic was uniquely engineered to correlate a cell’s instruction with its function by capturing both mRNA expression data and highly-multiplexed, functional protein activity.

Technological advances in single-cell research are trending towards developing multi-omics methods to reveal deep relationships across the unique-omes.

While the transcriptome is widely studied in single-cell biology, transcriptome data alone does not fully correlate to cellular function.

The next frontier must integrate in vivo proteomic activity from cells with the gene regulatory networks driving those reactions.


IsoPlexis’ single-cell functional proteomics addresses this gap by capturing unique, highly multiplexed functional proteins from single cells.

The efficacy of our technology is shown across predictive data sets, from “superhero” orchestrator immune cells, tumor cells, stem cells, and more.

Our latest innovation, Duomic, enables you to link both transcriptomic and functional proteomics data (e.g. cytokines, chemokines, growth factors, phosphoproteins) directly from the same single cell across many cells in parallel.

The Next Frontier of Biology

Reveal gene networks associated with proteomically driven “superhero” orchestrator cells, which drive early predictive therapeutic responses in a variety of disease areas.


Accelerate insights and unlock answers that empower you to understand and tune the gene networks that can create optimal therapeutic responses amongst heterogenous cells.


Leverage analytics to understand and better control and apply complex biology to influence the course of immunotherapies at the genetic and proteomic level.

Your Discovery Workhorse to Translational Predictive Medicine
Fully characterize and link cellular function to patient outcomes, treatment response, or disease progression, by identifying highly functional "superhero" cells orchestrating response.
Identify which genes and gene pathways have a downstream impact on protein heterogeneity in these “superhero” cells.
Gain insights into cell behavior and reveal gene networks associated with these “superhero cells”.
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Contact us to learn more about how Duomic helps visionary researchers like you accelerate in vivo biology by identifying correlations between a cell's instruction and its actual function.

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Duomic: Transcriptomics + Functional Proteomics

Duomic brings transcriptomics and functional proteomics together on a single chip to create an integrated cell behavior platform — providing critical insights missed by single analyte methodologies.

Connect the dots between a cell’s instruction and function
Harness bioinformatics with automated analysis
Gain confidence in your conclusions, faster