Follow the Data: T cell polyfunctional subsets in SLE determine contribution to pathogenesis and potential targets1

Research Area: Inflammatory & autoimmune disease

Development Stage: Discovery

Goal: Identify differences & mechanism in the expanded T cell populations within autoimmune disease

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How our single-cell systems are making a difference

Solution:  Polyfunctionality reveals key Tfh subsets that lead to disease progression in SLE

Finding: SLE patients exhibit polyfunctional TfH with B-helper cytokine IL-21 and effector cytokines IL-2, IFNγ and TNFα, indicating potential therapeutic targets based on source of disease progression

Follow the data

Polyfunctional cTFH cells as detected on the IsoCode, indicating healthy versus SLE patient differences and potential early stage biomarkers (left). The expanded population in SLE is polyfunctional and produces elevated levels of B-helper cytokine IL-21 and effector cytokines IL-2, IFN-γ and TNF-α.1

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