Make a Difference in Accelerating & Optimizing Your Cell Therapy Programs

[unex_ce_button id="content_1khp77dvb,column_content_rcfcgn7j5" button_text_color="#ffffff" button_font="bold" button_font_size="18px" button_width="full_width" button_alignment="center" button_text_spacing="1px" button_bg_color="#0fa8db" button_padding="15px 20px 15px 20px" button_border_width="0px" button_border_color="#0fa8db" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#87c6db" button_border_hover_color="#87c6db" button_link="https://www.isoplexis.com/request-a-seminar" button_link_type="url" button_link_target="_blank" has_container="" in_column="1"]Request a seminar >[/ce_button]

IsoPlexis is empowering cell therapy development across the discovery-optimize-predict continuum

From discovery to the clinic, researchers are developing a far more complicated cell based product to address a variety of cancers therapeutically. To characterizate these solutions, more detail is needed to address challenges related to potency, durability and toxicities that correlate to what is happening in vivo within the cell therapy.

IsoPlexis has worked with leaders to develop data correlating with response:

In each stage of cell engineering & therapy development

  • Lead choice in CRISPR edited cell therapy Data >
  • Optimization of bioprocessing in CAR-T Data >
  • Pre-infusion product CAR-T biomarkers Data >

In various cell therapies and cell types

  • CD19 CAR-T therapy Data >
  • NK cell therapy Data >
  • Bispecific CAR-T therapy Data >
  • Cell therapy combined with agonists Data >
  • Cell therapeutic vaccines Data >

Literature:
Cell Engineering & Therapy

Join us to learn more about how we are accelerating cell therapy programs across the discover-optimize-predict continuum with our unique cellular analysis metrics.

[unex_ce_button id="content_jc8vbslgl,column_content_6k1nhbixn" button_text_color="#00b1d8" button_font="bold" button_font_size="18px" button_width="auto" button_alignment="left" button_text_spacing="1px" button_bg_color="#efefef" button_padding="10px 20px 10px 20px" button_border_width="0px" button_border_color="#efefef" button_border_radius="0px" button_text_hover_color="#00b1d8" button_text_spacing_hover="1px" button_bg_hover_color="#d6d6d6" button_border_hover_color="#d6d6d6" button_link="https://www.isoplexis.com/CellT-P" button_link_type="url" button_link_target="_blank" has_container="" in_column="1"]Download application note >[/ce_button]

Follow our correlative data across the cell therapy development spectrum, in multiple cell types & indications

[unex_ce_button id="content_nu8khu7py,column_content_558u0089c" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#ff6d1d" button_padding="10px 48px 10px 48px" button_border_width="0px" button_border_color="#ff6d1d" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#ff6d1d" button_border_hover_color="#ff6d1d" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]ENABLING DISCOVERY[/ce_button]

IsoPlexis' systems are revealing cellular potency differences resulting from subtle CRISPR gene edits to NK cells

[unex_ce_button id="content_nu8khu7py,column_content_iujebq31d" button_text_color="#ff5c05" button_font="bold" button_font_size="14px" button_width="auto" button_alignment="right" button_text_spacing="1px" button_bg_color="#ededed" button_padding="10px 15px 10px 15px" button_border_width="0px" button_border_color="#efefef" button_border_radius="0px" button_text_hover_color="#ff6d1d" button_text_spacing_hover="1px" button_bg_hover_color="#d6d6d6" button_border_hover_color="#d6d6d6" button_link="https://www.isoplexis.com/discover-cell-therapy" button_link_type="url" button_link_target="_blank" has_container="" in_column="1"]Follow our data >[/ce_button]
[unex_ce_button id="content_nu8khu7py,column_content_xdjj0vpoy" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#0fa8db" button_padding="10px 18px 10px 18px" button_border_width="0px" button_border_color="#0fa8db" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#0fa8db" button_border_hover_color="#0fa8db" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]OPTIMIZING BIOPROCESSING[/ce_button]

Our products help identify methodologies for increasing potency in cell therapy bioprocessing

[unex_ce_button id="content_nu8khu7py,column_content_0su52fzur" button_text_color="#34bad8" button_font="bold" button_font_size="14px" button_width="auto" button_alignment="right" button_text_spacing="1px" button_bg_color="#efefef" button_padding="10px 15px 10px 15px" button_border_width="0px" button_border_color="#efefef" button_border_radius="0px" button_text_hover_color="#34bad8" button_text_spacing_hover="1px" button_bg_hover_color="#d6d6d6" button_border_hover_color="#d6d6d6" button_link="https://www.isoplexis.com/optimize-cell-therapy" button_link_type="url" button_link_target="_blank" has_container="" in_column="1"]Follow our data >[/ce_button]
[unex_ce_button id="content_nu8khu7py,column_content_xtfr9xyp8" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#4e8200" button_padding="10px 43px 10px 43px" button_border_width="0px" button_border_color="#4e8200" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#4e8200" button_border_hover_color="#4e8200" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]PREDICTING RESPONSE[/ce_button]

Our systems are identifying pre-infusion cell therapy product metrics (PSITM) that correlate with in vivo outcome

[unex_ce_button id="content_nu8khu7py,column_content_sdxbifvxt" button_text_color="#4e8200" button_font="bold" button_font_size="14px" button_width="auto" button_alignment="right" button_text_spacing="1px" button_bg_color="#efefef" button_padding="10px 15px 10px 15px" button_border_width="0px" button_border_color="#efefef" button_border_radius="0px" button_text_hover_color="#4e8200" button_text_spacing_hover="1px" button_bg_hover_color="#d6d6d6" button_border_hover_color="#d6d6d6" button_link="https://www.isoplexis.com/predict-cell-therapy" button_link_type="url" button_link_target="_blank" has_container="" in_column="1"]Follow our data >[/ce_button]

Publications & Presentations
Cell Engineering & Therapy

[unex_ce_button id="content_jx3qunf6n,column_content_rybl4703m" button_text_color="#ff5900" button_font="bold" button_font_size="18px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#efefef" button_padding="10px 20px 10px 20px" button_border_width="0px" button_border_color="#efefef" button_border_radius="0px" button_text_hover_color="#ff5900" button_text_spacing_hover="1px" button_bg_hover_color="#d6d6d6" button_border_hover_color="#d6d6d6" button_link="https://www.isoplexis.com/request-a-seminar" button_link_type="url" button_link_target="_blank" has_container="" in_column="1"]Contact us for a seminar
on our datasets >[/ce_button]

Notch activation rescues exhaustion in CISH-deleted natural killer cells to promote in vivo persistence and enhance anti-tumor activity. Zhu H, Blum RH, Wu Z, Bahena A, Hoel HJ, Ask EH, Guan KL, Malmberg KJ, Kaufman DS. Presented at ASH Annual Meeting 2018.

Aged CAR T cells exhibit enhanced cytotoxicity and effector function but shorter persistence and less memory-like phenotypes. Kotani H, Li Gongbo, Yao Jiqiang, Mesa TE, Chen J, Boucher JC, Yoder SJ, Zhou J, Davila ML. Presented at ASH Annual Meeting 2018.

Single-Cell Multiplexed Cytokine Profiling of CD19 CAR-T Cells Reveals a Diverse Landscape of Polyfunctional Antigen-Specific Response. Xue Q, Bettini E, Paczkowski P, Ng C, Kaiser A, McConnell T, Kodrasi O, Quigley M, Heath JR, Fan R, Mackay S, Dudley M, Kassim S, and Zhou J. Journal for ImmunoTherapy of Cancer, 5:85 (2017).

Single-Cell Proteomic Assessment of CD19 CAR-T Cells Reveals a Complex Landscape of Polyfunctional Antigen-Specific Response. Xue Q, Bettini E, Paczkowski P, Ng C, Kaiser A, McConnell T, Kodrasi O, Quigley M, Heath JR, Fan R, Mackay S, Dudley M, Kassim S, and Zhou J. Presented at FOCiS Annual Meeting 2017.

Preinfusion Polyfunctional Anti-CD19 Chimeric Antigen Receptor T Cells Associate with Clinical Outcomes in NHL. Rossi J, Paczkowski P, Shen Y, Morse K, Flynn B, Kaiser A, Ng C, Gallatin K, Cain T, Fan R, Mackay S, Heath JR, Rosenberg SA, Kochenderfer JN, Zhou J, and Bot A. Blood 2018.

Unlock the IsoPlexis

Single-Cell Webinar Series 

Your data is in safe hands. View Privacy Policy

Unlock the IsoPlexis

Technology Overview Series

Your data is in safe hands. View Privacy Policy