Using IsoPlexis’ Functional Cell Library to Advance Single-Cell Research

IsoPlexis’ highly multiplexed single-cell solutions uniquely reveal the rare subsets of highly polyfunctional cells whose function is predictive of patient response and survival. Our unique biology has been used on a wide variety of cell types across applications and research areas. Though single-cell analysis has historically been challenging, IsoPlexis’ functional proteomics platform provides researchers a powerful and accessible tool to gain unique insights into individual cell function to uncover drivers of the immune response.

To make this unique data easily available, IsoPlexis has created the Functional Cell Library, a catalog of all the cell types that have been functionally phenotyped with our unique biology. By aggregating all of the existing peer-reviewed single-cell functional data, the Functional Cell Library provides researchers a powerful tool to understand how single-cell analysis can supercharge research, identify relevant case studies, and plan next-level, breakthrough  experiments.

Explore the Library

The Functional Cell Library is divided into three categories that highlight how cells’ functions drive in vivo biology:

  • Supercharged Immunology – Highly polyfunctional cells are responsible for driving the immune response and act as biomarkers for potency, persistence, and survival. Characterizing the function of these cells has given researchers a better understanding of the mechanisms underlying treatment response and efficacy and can help to inform the development of future therapies.
  • Hyperinflammation – Overactive immune cells have been shown to promote disease via maladaptive inflammation. By pinpointing the highly polyfunctional immune cells that drive infectious disease including COVID-19, neurodegenerative disorders, and other immune-related disorders, researchers can identify mechanisms of disease and ultimately prevent hyperinflammation to improve outcomes.
  • Aberrant Malignancies – Highly phosphoproteomically active cells drive cancer progression and treatment resistance. Uncovering single-cell intracellular signaling networks provides unique insights into how cell signaling pathways are altered within rare cancer cell subpopulations for better targeted therapies.

Planning Your Next Projects with the Functional Cell Library

Researchers can easily explore the Functional Cell Library to identify publications and experiments of interest. Each category is comprised of publications which are easily sortable by cell type, biomarker, and applications. All entries in the Functional Cell Library provide links to relevant protocols to facilitate experimental planning. The ability to easily reference published methodologies and IsoPlexis’ validated protocols enables researchers to quickly understand the conditions, cell types, and steps necessary to prepare their samples for their own IsoPlexis single-cell projects. The Functional Cell Library serves as an easy-to-use resource that makes single-cell functional data navigable while being freely available to all researchers.

Single-cell proteomic analysis has yielded numerous insights into cell function and response that would be impossible with status quo technologies, and the Functional Cell Library helps to link published single-cell function with in vivo biology. By compiling these findings into a valuable tool, the Functional Cell Library gives researchers the ability to leverage existing unique in vivo functional insights to accelerate early-stage, translational and clinical research. In doing so, researchers can gain a better understanding of the cellular mechanisms driving disease and treatment response, refine therapies, and ultimately improve patient outcomes.

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