The Structure and Functions of the p53 Pathway: Information Acquisition, Redundancy, and Connectivity
On June 30th, learn about how p53 has changed the field of cancer research since its discovery in 1979 by Dr. Levine. More than half of all human cancers have a mutated form of this tumor protein, demonstrating the importance of it’s continuous study. Dr. Levine will also discuss what’s still left to uncover when it comes to p53.
Topics that will be covered:
- The foundational discovery of p53 and its recent advances
- How changes in MDM2-p53 signaling affects the timing and development of tumors
- The affect of signaling networks on cancer therapy resistance
- Using single-cell phosphoproteomics to identify key signaling events in glioblastoma
- Altering signaling coordination to mitigate adaptive resistance