Cytokine Profiling with CodePlex Leads to Druggable Targets to Treat Cancer Metastasis
We recently held a webinar in partnership with the Scientist with featured speaker, Dr. Denis Wirtz of Johns Hopkins University. Dr. Wirtz is the Theophilus Halley Smoot Professor in the Department of Chemical and Biomolecular Engineering and Vice Provost for research at Johns Hopkins University. He also directs the Johns Hopkins Physical Sciences-Oncology Center and co-directs the Cancer Nanotechnology Training Center. This webinar, titled “Understanding Cancer Cell Communication to Infer a Strategy to Inhibit Tumor Cell Migration,” discussed how cytokine profiling helped researchers develop a potential therapy to inhibit metastasis and improve cancer patient outcomes.
Topics covered in this webinar:
- How cell density and proliferation affect tumor cell metastasis and how they shape the development of novel therapies
- How cytokine profiling and highly multiplexed proteomic analysis of three-dimensional models help identify proteins encouraging cell migration
- How identifying a potential mechanism promoting tumor cell migration enables the development of a strategy to decrease tumor cell metastatic capacity
Dr. Wirtz is known for his work in many areas, but most notably for his research in cell motility and adhesion. His group’s work in studying cells in a natural, 3D environment as opposed to the traditional 2D method led him to make the connection that the local microenvironment affects how cells migrate. Cytokine profiling in the tumor microenvironment, as provided by IsoPlexis’ technology, can provide predictive data that correlate with cell behavior. With Dr. Wirtz’s vast knowledge in this space, we created a webinar where he could discuss the findings of his paper, “Synergistic IL-6 and IL-8 paracrine signalling pathway infers a strategy to inhibit tumour cell migration.”
In case you missed it, the webinar is available now to watch on-demand.