Dr. Arnold Levine Webinar: The Structure and Functions of the p53 Pathway

On-Demand Webinar Discusses Information Acquisition, Redundancy, and Connectivity of p53

One of IsoPlexis’ key scientific advisory board members, Dr. Arnold J. Levine, who discovered p53, recently published an article discussing the years since the discovery of p53 as well as the 800+ million years of its evolution. Dr. Levine highlights what has been learned about this protein since it’s discovery and what is still unknown. This tumor protein has transformed the field of cancer research as the pathway’s signaling plays a crucial part in the regulation of the cell cycle, including preventing mutations from DNA damage or stress.

Dr. Levine’s article, “p53: 800 million years of evolution and 40 years of discovery” is the central focus for a recent webinar held by The Scientist titled “The Structure and Functions of the p53 Pathway: Information Acquisition, Redundancy, and Connectivity,” now available on-demand. This webinar also features the single-cell phosphoproteomic technology from IsoPlexis that is able to identify changes in tumor signaling pathways such as p53 in order to help researchers optimize their immune therapies and prevent drug resistance.

Over half of all human cancers contain a mutation in the p53 gene, which “suggests that the MDM2-p53 hub and pathway is important for tumor suppression, and understanding this pathway in detail can be useful for our understanding of human cancers.”1 This webinar with Dr. Levine discusses what is still left to learn about this tumor protein, what has already been established since its discovery, and how that has helped the field.

p53 pathway

Figure 1 adapted from Levine AJ. “p53: 800 million years of evolution and 40 years of discovery.” Nature Reviews Cancer 188, 2020.

Above is one of the figures from Dr. Levine’s recent article, depicting the various stress signals that can activate the p53 pathway. Besides being so prevalent among human cancers, with the vast amount of stress signals activating this tumor protein, it’s clear that learning more about p53 will help uncover more vital information needed to treat cancer. “The core of the p53/p63 pathway, DNA damage input and apoptosis output in the germ line, has been preserved during 600-800 million years of evolution. This validates the importance of this pathway for the organism.”1

To learn more about the discovery of p53 and the evolution of the field since then, how single-cell phosphoproteomics can help identify changes in signaling networks such as p53, and how changes in signaling can affect treatment resistance in cancers such as glioblastoma, watch the on-demand webinar now.

 

Arnold Levine Webinar

Reference:

  1. Levine AJ. p53: 800 million years of evolution and 40 years of discovery. Nature Reviews Cancer 188, 2020.
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