New analysis methods fuel the advancement of scientific research, providing novel insights while broadening the scope of future research questions and areas of interest. Over the last decade, single-cell analysis techniques have been named a method of the year multiple times by Nature Methods. Single-cell functional analysis has become a critical tool used to help better inform both therapy development and the mechanisms of complex diseases, and IsoPlexis has consistently been at the forefront of these developments by empowering researchers to uncover new layers of single-cell data and transform them into actionable insights.
In 2022 alone, the IsoPlexis platform has been utilized in groundbreaking studies ranging from preclinical and basic research to clinical research and manufacturing. Below is a sampling of just some of the many publications that have drawn on insights generated by the IsoPlexis platform this year.
- Published in the Journal for ImmunoTherapy of Cancer: Single-cell analysis was used to identify biomarkers of clinical benefit of combination therapy in advanced melanoma
- Published in Cell: Researchers identified the cells and immune profiles that lead to long COVID
- Published in Science Advances: By analyzing immune cells at the single-cell level, researchers were able to verify that their engineered hydrogel helped to direct monocytes and macrophages to a pro-healing state
- Published in Nature Genetics: The signaling pathway that causes cancer when the CCL22 gene is mutated was revealed for the first time with single-cell analysis
- Published in Science Advances: Metrics of single-cell function were used to create biomarkers of CAR-T response and relapse
- Published in Frontiers in Medical Technology: Researchers used single-cell functionality to evaluate scalable T cell manufacturing methods
- Published in Cancer Immunology Research: CAR-T cells targeting solid tumors using a novel strategy to prevent immunosuppression were characterized and shown to be more effective at controlling tumor growth
- Published in the Journal of the American Society of Nephrology: Single-cell analysis revealed peripheral biomarkers related to organ transplant rejection
- Published in the Journal of Experimental and Clinical Cancer Research: Studying immune cell function at the single-cell level showed how tumor cells suppress immune function, leading to tumor progression
These findings, across a variety of diseases, all help to improve current treatments and understanding of disease etiology and progression. Looking into 2023 and beyond, single-cell functional analysis will continue to play a transformative role into the future of the advanced medicine landscape, and IsoPlexis is proud to be a key partner in this new era of biology.
