Application: Single-Cell Tumor Resistance

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IsoPlexis’ Single-Cell Tumor Resistance solution is revealing highly functionally active subsets of tumor cells, which drive resistance

From discovery to the clinic, IsoPlexis’ single-cell tumor resistance solution is helping researchers understand how to dissect and reveal the pathways that are adapting to the therapy and driving resistance. IsoPlexis’ FHI, Functional Heterogeneity Index, and SNAI, Signaling Network Activity Index, are revealing the resistant pathways in tumor cells that can reveal how to design therapeutic strategies that target this resistance directly.

This tumor signaling and pathway analysis is making the difference:

In various tumor types

From discovery to target optimization

  • Combination kinase inhibitor research Data >
  • Melanoma pathway prediction Data >

How it works:
Single-Cell Tumor Resistance

Our chip measures the range of 32 intracellular proteins and phosphoproteins that capture key druggable pathways and dictate resistance to therapy

This panel is measured from each of 1000+ single tumor cells

The early precursor cells that dictate resistant pathways are detected

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Follow IsoPlexis' correlative data across solid tumor & oncology therapy development stages

[unex_ce_button id="content_gwh1gqeip,column_content_558u0089c" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#ff6d1d" button_padding="10px 48px 10px 48px" button_border_width="0px" button_border_color="#ff6d1d" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#ff6d1d" button_border_hover_color="#ff6d1d" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]ENABLING DISCOVERY[/ce_button]

Our SNAI has identified drug-induced resistance in a correlative manner that can be targeted therapeutically

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[unex_ce_button id="content_gwh1gqeip,column_content_xdjj0vpoy" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#0fa8db" button_padding="10px 38px 10px 38px" button_border_width="0px" button_border_color="#0fa8db" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#0fa8db" button_border_hover_color="#0fa8db" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]OPTIMIZING TARGETING[/ce_button]

IsoPlexis' heterogeneity index is predicting cancer resistance, enabling development of novel combination treatments

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[unex_ce_button id="content_gwh1gqeip,column_content_xtfr9xyp8" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#4e8200" button_padding="10px 43px 10px 43px" button_border_width="0px" button_border_color="#4e8200" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#4e8200" button_border_hover_color="#4e8200" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]PREDICTING RESPONSE[/ce_button]

Our products are uncovering correlations of TIL function in solid tumors, which can be used for targeting

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Literature:
Single-Cell Tumor Resistance

Join us to learn more about single-cell tumor resistance readouts and related pathway signaling metrics are accelerating a variety of oncology programs from discovery to predicting response

 

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