Application: Single-Cell Polyfunctional Strength

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IsoPlexis’ single-cell polyfunctional strength solution, and its PSITM index is uniquely capturing key measures of potency & durability

From discovery to the clinic, IsoPlexis’s Single-Cell Polyfunctional Strength solution is helping researchers understand how to capture unique potency and durability metrics that correlate to in vivo activity. It does this by detecting the most potent cell subsets, based on the ability of each cell to secrete multiple cytokines simultaneously, at a high intensity.

These highly polyfunctional cells are making the difference:

In various immune cell types

  • T cells in immunotherapy Data >
  • NK cells in gene editing Data >
  • Myeloid cells (macrophages, monocytes) Data >

In various therapy types

  • Cell therapies Data >
  • Checkpoint inhibitors Data >
  • Agonists, i.e., pegylated cytokines Data >
  • Small molecule pathway inhibitors
  • Vaccines Data >

How it works:
Single-Cell Polyfunctional Strength

Our chip measures the range of 32 cytokines that orchestrate the T-cell response in immunotherapy

This panel is measured from each of 1000+ single cells

The most potent cells that secrete multiple cytokines at high intensities, i.e. polyfunctional cells, are captured uniquely

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Follow IsoPlexis' correlative data, driven by the Single-Cell Polyfunctional Strength solution

[unex_ce_button id="content_nu8khu7py,column_content_558u0089c" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#ff6d1d" button_padding="10px 48px 10px 48px" button_border_width="0px" button_border_color="#ff6d1d" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#ff6d1d" button_border_hover_color="#ff6d1d" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]ENABLING DISCOVERY[/ce_button]

IsoPlexis' systems are revealing cellular potency differences resulting from subtle CRISPR gene edits to NK cells

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[unex_ce_button id="content_nu8khu7py,column_content_xdjj0vpoy" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#0fa8db" button_padding="10px 18px 10px 18px" button_border_width="0px" button_border_color="#0fa8db" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#0fa8db" button_border_hover_color="#0fa8db" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]OPTIMIZING BIOPROCESSING[/ce_button]

Our products help identify methodologies for increasing potency in cell therapy bioprocessing

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[unex_ce_button id="content_nu8khu7py,column_content_xtfr9xyp8" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#4e8200" button_padding="10px 43px 10px 43px" button_border_width="0px" button_border_color="#4e8200" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#4e8200" button_border_hover_color="#4e8200" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]PREDICTING RESPONSE[/ce_button]

Our systems are identifying pre-infusion cell therapy product metrics (PSITM) that correlate with in vivo outcome

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Literature:
PSITM, IsoPlexis' Polyfunctional Strength Index

Join us to learn more about how PSITM and related IsoPlexis polyfunctional metrics are accelerating immunotherapy programs from discovery to predicting response

 

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See how our IsoSpeak Software enables your team to generate insights with PSITM right away

Powerful Visualizations: Well published immune polyfunction visualizations that simplify complex single-cell data accessed directly

End to end: Start to finish informatics and statistics that enables comparisons & answers in potency & durability, from one piece of software

Annotate & Organize: Tools provide in-software sample annotations & project organization for immunotherapy workflows

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