Application: Single-Cell Innate & Myeloid

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IsoPlexis’ single-cell innate & myeloid solution is detecting measures of both function and dysfunction that correlate to in vivo response

From discovery to the clinic, IsoPlexis’ Single-Cell Innate & Myeloid solution is helping researchers understand how to capture unique potency and cellular function and dysfunction metrics that correlate to in-vivo activity, from these ‘early responder’ cell types. It does this by detecting the most active cell subsets, based on the ability of each cell to secrete various quantites and types of cytokines simultaneously, at a high intensity.

These intense and active innate cells are making the difference:

In various innate immune cell types

  • NK cells in gene editing Data >
  • Myeloid cells (macrophages)
  • NK cells in autoimmune
  • Monoctyes in autoimmune

In various areas of both potency and dysfunction

  • Cell therapies Data >
  • Autoimmune progression & targeting Data >
  • TLR response in research

How it works:
Single-Cell Innate & Myeloid

Our chip measures the range of 32 growth factors, chemokines and cytokines that orchestrate innate cell response in a variety of contexts

This panel is measured from each of 1000+ single cells

The most potent cells that secrete multiple proteins are detected

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Follow IsoPlexis' correlative data across innate & myeloid research & therapy development

[unex_ce_button id="content_7ceqvmvi5,column_content_558u0089c" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#ff6d1d" button_padding="10px 48px 10px 48px" button_border_width="0px" button_border_color="#ff6d1d" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#ff6d1d" button_border_hover_color="#ff6d1d" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]ENABLING DISCOVERY[/ce_button]

IsoPlexis' systems are revealing cellular potency differences resulting from subtle CRISPR gene edits to NK cells

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Our products uncover the innate cell mechanism driving disease progression, which helps reveal optimal targets

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Our systems have stratified patients by CRS (cytokine release syndrome) in cell therapy, pre-infusion

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Literature:
Single-Cell Innate & Myeloid

Join us to learn more about how single-cell innate & myeloid readouts and related polyfunctional and dysfunctional metrics are accelerating a variety of immune related programs from discovery to predicting response

 

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See how our IsoSpeak Software enables your team to generate innate cell insights right away

Powerful Visualizations: Well published immune polyfunction visualizations that simplify complex single-cell data accessed directly

End to end: Start to finish informatics and statistics that enables comparisons & answers in potency & durability, from one piece of software

Annotate & Organize: Tools provide in-software sample annotations & project organization for immunotherapy workflows

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