Application: Single-Cell Inflammation

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IsoPlexis’ single-cell inflammation is revealing highly dysfunctional subsets of immune cells that can be targeted by therapies

From discovery to the clinic, IsoPlexis’s single-cell Inflammation solution is helping researchers understand how to capture dysfunction of key cell types that are typically missed, and that also correlate to in vivo progression. The data demonstrates that these highly active subsets of heterogenous cells influence progression in a way that can be both detected on IsoPlexis’ systems, and thus targeted for downregulation.

See where this data is making a difference:

In various autoimmune areas

  • Multiple sclerosis Data >
  • SLE (systemic lupus) Data >
  • Crohn's disease
  • Cytokine release syndrome in oncology Data >

How it works:
Single-Cell Inflammation

Our chip measures the range of 32 cytokines and chemokines that orchestrate inflammatory T cell response in a variety of contexts

This panel is measured from each of 1000+ single cells

The most dysfunctional cells that secrete multiple proteins at a high intensity are detected

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Follow IsoPlexis' correlative data across inflammatory & autoimmune disease therapy development

[unex_ce_button id="content_u3n4cnw4e,column_content_558u0089c" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#ff6d1d" button_padding="10px 48px 10px 48px" button_border_width="0px" button_border_color="#ff6d1d" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#ff6d1d" button_border_hover_color="#ff6d1d" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]ENABLING DISCOVERY[/ce_button]

IsoPlexis systems are revealing differences in T cell subtypes that correlate with SLE (systemic lupus) progression

[unex_ce_button id="content_u3n4cnw4e,column_content_iujebq31d" button_text_color="#ff5c05" button_font="bold" button_font_size="14px" button_width="auto" button_alignment="right" button_text_spacing="1px" button_bg_color="#ededed" button_padding="10px 15px 10px 15px" button_border_width="0px" button_border_color="#efefef" button_border_radius="0px" button_text_hover_color="#ff6d1d" button_text_spacing_hover="1px" button_bg_hover_color="#d6d6d6" button_border_hover_color="#d6d6d6" button_link="https://www.isoplexis.com/discover-autoimmune-disease" button_link_type="url" button_link_target="_blank" has_container="" in_column="1"]Follow our data >[/ce_button]
[unex_ce_button id="content_u3n4cnw4e,column_content_xdjj0vpoy" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#0fa8db" button_padding="10px 38px 10px 38px" button_border_width="0px" button_border_color="#0fa8db" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#0fa8db" button_border_hover_color="#0fa8db" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]OPTIMIZING TARGETING[/ce_button]

Our products uncover the innate cell mechanism driving disease progression, which helps reveal optimal targets

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[unex_ce_button id="content_u3n4cnw4e,column_content_xtfr9xyp8" button_text_color="#ffffff" button_font="bold" button_font_size="16px" button_width="auto" button_alignment="center" button_text_spacing="1px" button_bg_color="#4e8200" button_padding="10px 43px 10px 43px" button_border_width="0px" button_border_color="#4e8200" button_border_radius="0px" button_text_hover_color="#ffffff" button_text_spacing_hover="1px" button_bg_hover_color="#4e8200" button_border_hover_color="#4e8200" button_link="" button_link_type="url" button_link_target="_self" has_container="" in_column="1"]PREDICTING RESPONSE[/ce_button]

Our systems have stratified patients by CRS (cytokine release syndrome) in cell therapy, pre-infusion

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Literature:
Single-Cell Inflammation

Join us to learn more about how single-cell inflammation readouts and related dysfunction metrics are accelerating a variety of immune related programs from discovery to predicting response

 

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See how our IsoSpeak Software enables your team to generate inflammatory cell insights right away

Powerful Visualizations: Well published immune visualizations that simplify complex single-cell data accessed directly

End to end: Start to finish informatics and statistics that enables comparisons & answers in potency & durability, from one piece of software

Annotate & Organize: Tools provide in-software sample annotations & project organization for immunotherapy workflows

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