Powerful Biology
Accelerating the
Future of Medicine

The future of advanced medicines relies upon deeper access to in vivo biology to create durable, curative impacts on disease. Our systems, which drive convergence of dynamic proteomics and single cell biology for the first time, are creating this deeper connection to accelerate curative medicines.

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Introducing IsoSpark
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Introducing the IsoSpark

A personalized functional
proteomics system for any lab.

Bridging the Gap to Accelerate Medicine

Isoplexis captures proteomics reflecting in vivo biology with walk-away automation to cut therapeutic development timelines and add efficacy

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Proteins Reflecting & Predicting
in vivo Biology

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High MultiPlex from Single Cells & Bulk Captures Complexity

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Time Saved with
Analytics Automation

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Single-Cell Functional Proteomics Hub

Accelerate your therapeutics and biomarkers
with an all-in-one integrated system

Learn More
Our Solutions

The Products Driving Our Superpowered Biology

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Better Biomarkers,
Accelerated Development
Functional Immune
Landscaping

Accelerate the ability to clarify lead candidate choice and durable biomarkers using the proteomic secretome from each single cell to accelerate path to the clinic and higher efficacy with targeted immune therapies. 

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Accelerated Discovery
and Targeting
Intracellular Signaling
Omics

Identify adaptive phosphoproteomic signaling networks from rare subsets of single tumor and other cell types, leveraging single cell proteomics to treat the entire set of signaling pathways concurrently, and eliminate resistance and metastases.

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Sample to Insights,
for Any Lab
High-plex Walk-Away
Immunoassays

For the first time, unleash walk-away multiplexed proteomics in very low sample volumes, with an analytics suite that saves resources and time while delivering key omic insights.
 

Technology

Superpowered Biology Built on a Strong Foundation

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Our Unique Biology
Immune
Cells
Immune
Cells
Tumor

Proteomics, Reimagined to uniquely detect our most powerful cells.

Explore Our Biology

Instrument Virtual Demo
Virtual Demo
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The entire ELISA proteomics workflow, sample to answer.

Take the Virtual Tour

Data Visualization Tour
t-SNE
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IsoSpeak Software: Same day visualizations and insights.

Tour the Visualizations

Publications

See how top researchers are using our technology to predict durable responses and unlock pre-clinical meaning.

View All Publications
CAR T cells with dual targeting of CD19 and CD22 in adult patients with recurrent or refractory B cell malignancies: a phase 1 trial
Jay Y. Spiegel et al., Nature Medicine. 2021.
View Publication
Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma
Adi Diab et al., Journal of Clinical Oncology. 2021.
View Publication
Multi-omics resolves a sharp disease-state shift between mild and moderate COVID-19
Yapeng Su et al., Cell . 2020.
View Publication
Areas of Interest

See how we can shift the paradigms in your programs

Cancer
Immunology
IsoPlexis’ Functional Immune landscaping for liquid T cell biopsies is showing which therapies work with which patients with unique insights.
Cell
Therapy
Quality Analytics with IsoPlexis’ functional immune landscaping are shaping the future of cell therapy and enabling more efficient manufacturing, higher quality cell therapies, and improved patient outcomes.
Infectious
Disease
COVID-19 and other complex diseases are being advanced with IsoPlexis’ functional immune-landscaping and high-plex automated immunoassays to speed insights.
Inflammation
IsoPlexis’ high-plex automated immunoassays and functional immune landscaping are providing immediate insights into the drivers of immune inflammation.
Targeted
Therapies
IsoPlexis’ intracellular signaling omics are revealing mechanisms of the functional cellular adaptations leading to resistance and providing insights for the development of better targeted therapies.
Updates

Enabling a New Era of Precision Medicine

Latest Customer Stories View Blog

IsoPlexis_Blog Post_Progression-Free Survival in Melanoma (1)
Jul 23
IsoPlexis’ Single-Cell Proteomics Predict Progression-Free Survival in Melanoma Study
Cancer Immunology
Blog Post_CAR NK Cells Shed Light on Improved Transduction Method (1)
Jul 16
Single-Cell Functional Proteomic Characterization of CAR NK Cells Sheds Light on Improved Transduction Method
Cell Therapy
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Jul 09
Single-Cell Proteomics Helps to Uncover a Regulatory Mechanism of NK Cell Functionality
Cancer Immunology

Featured Events All Events

Webinar: Highly Multiplexed Single-Cell Proteomics Identifies Key Inflammatory Mediators in Severe COVID-19
Webinar
 July 29th | VIRTUAL
View Event
13th Annual Bioprocessing Summit
Conference
 Aug 16 - 19 | VIRTUAL
View Event
CAR-TCR US 2021
Conference
 Aug 30 - Sep 2 | VIRTUAL
View Event

Featured Content

The IsoSpark Brochure

Accelerate immune medicine across research areas & high-impact applications. All in one, beautifully designed and intuitive system that fits on any lab bench. Across all applications, discover immune profiling insights unattainable with any other system.

Download Now
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Trusted Worldwide

We innovated the only way to measure the true function of each cell and identify the rare subsets of superpowered cells driving response.

As a cancer research center with a key focus on CAR-T and other cell therapies, we feel that IsoPlexis will enable us to better characterize response and potentially predict whether cancer patients will respond to CAR-T therapy before treatment.
Christine Brown

City of Hope

The ability of the IsoLight to provide detailed analyses from very few cells is key, given that we are limited to small sample quantities of blood.
Petter Brodin, MD PHD

Associate Professor of Immunology at Karolinska Institute

Quality assays are mainly descriptive with some objective parameters like cytokine production, cytotoxicity, and proliferation. Only recently, with PSI… can we start to differentiate products.
Marco L Davila

Moffitt Cancer Center

We see potential in utilizing IsoPlexis’ single-cell system to help provide deeper resolution into the functional impacts of our therapeutics… This collaboration will enable us to apply the sensitivity of this solution to further our understanding of patient-specific responses to our immune therapies.
Jon Zalevsky

Chief Scientific Officer, Nektar Therapeutics

Through this research, we were able to highlight the important role a functionally versatile subpopulation of CAR-T cells may play in the fight against cancer. This could lead to new methods to optimize T-cell products.
Adrian Bot, MD

Vice President, Translation Sciences, Kite

Current assays that rely on a single-plex ELISA or even multiparametric flow cytometry don’t give you the level of resolution that the IsoPlexis platform can provide.
John Rossi

Director of Translational Sciences at Kite

Spark the Next Breakthrough
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