Precision Profiling

...predictive single cell response.

Our technology and applications enable improved targeting of complex treatments to the cancer patients who need them most. Scientific leaders at Yale and Caltech developed the IsoPlexis precision engineering platform to detect the full (omic) set of functions from thousands of single patient cells. This unprecedented quantity and quality of data from single cells is providing breakthrough clinical biomarker insights into highly urgent areas of oncology today.

CAR T Cell Functionality Correlates With Outcomes, Offering a Biomarker...

For the biomarker assessment, PSI was determined by an analysis of pre-infusion CAR T cells using a single-cell, high-multiplexing ELISA system developed by IsoPlexis...

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IsoPlexis and Kite Pharma research offers hope for targeted CAR-T treatment...

Research using IsoPlexis’s precision engineering platform shows the potential to predict whether cancer patients will respond to CAR-T cell therapy prior to treatment...

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Kicking Genomic Profiling to the Curb

In this issue of Cancer Cell, Wei et al. (2016) identify adaptive re-wiring of signaling nodes in glioma as major mechanisms of treatment resistance...

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Precision engineering platform developed at Yale and Caltech

The IsoPlexis IsoCode readout captures the omic end function from thousands of single cells in parallel to better understand complex patient response. The IsoCode chip, recognized in the literature as the SCBC, has been well validated in various immune and cancer detection applications, and has been making breakthroughs with UCLA, Memorial Sloan Kettering, and more.

Precision biomarker solutions in oncology areas of high complexity and high need

See how our versatile system uses its quantitative functional data, per cell, to enable more precise understanding of patient specific mechanisms of immune cell responses against cancer.

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Our Technology

The IsoCode chip (SCBC) captures the omic end function from thousands of single cells in parallel to better understand complex patient response.

The IsoLight automation system – available for early access later this year – provides a simple, integrated solution for running IsoCode assays in the lab.

The IsoSpeak software performs image processing, computation, and advanced informatics to compare single-cell function responses across patient groups.

JAK-STAT Pathway Activation in Malignant and Non-Malignant Cells Contributes to MPN... 

Cancer Discovery 2015

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Single-Cell Phosphoproteomics Resolves Adaptive Signaling Dynamics and Informs Targeted...

Cancer Cell 2016

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Multifunctional T-cell Analyses to Study Response and Progression in ACT Immunotherapy

Cancer Discovery 2013

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